1HYS

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	E	5'-R(*UP*CP*AP*GP*CP*CP*AP*CP*UP*UP*UP*UP*UP*AP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3'	polymer	23	7340.4	1
2	F	5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*TP*AP*AP*AP*AP*AP*GP*TP*GP*GP*CP*TP*G)-3'	polymer	22	6747.4	1
3	A	HIV-1 REVERSE TRANSCRIPTASE	polymer	553	63747.0	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus 1
4	B	HIV-1 REVERSE TRANSCRIPTASE	polymer	425	49562.0	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1
5	C	FAB-28 MONOCLONAL ANTIBODY FRAGMENT LIGHT CHAIN	polymer	214	22926.0	1		Mus musculus (house mouse)
6	D	FAB-28 MONOCLONAL ANTIBODY FRAGMENT HEAVY CHAIN	polymer	220	23457.2	1		Mus musculus (house mouse)

Sequence modifications

A: 1 - 553 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 447	engineered mutation

B: 1 - 425 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 447	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	173780.0
All*	Total formula weight	173780.0

*Water molecules are not included.