1RTD
STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE
Summary for 1RTD
Entry DOI | 10.2210/pdb1rtd/pdb |
Descriptor | DNA TEMPLATE FOR REVERSE TRANSCRIPTASE, DNA PRIMER FOR REVERSE TRANSCRIPTASE, PROTEIN (REVERSE TRANSCRIPTASE), ... (6 entities in total) |
Functional Keywords | complex(nucleotidyltransferase, dna, dntp), protein/dna, transferase-dna complex, transferase/dna |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P04585 |
Total number of polymer chains | 8 |
Total formula weight | 261133.52 |
Authors | Chopra, R.,Huang, H.,Verdine, G.L.,Harrison, S.C. (deposition date: 1998-08-26, release date: 1998-12-09, Last modification date: 2024-02-14) |
Primary citation | Huang, H.,Chopra, R.,Verdine, G.L.,Harrison, S.C. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science, 282:1669-1675, 1998 Cited by PubMed: 9831551DOI: 10.1126/science.282.5394.1669 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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