1ZYR

Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin

Summary for 1ZYR

Related1IW7 1SMY 1YNJ 1YNN 1K83 1I6H
DescriptorDNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase subunit beta' chain, ... (8 entities in total)
Functional Keywordsrna polymerase; streptolydigin; transcription; holoenzyme, transcription, transferase
Biological sourceThermus thermophilus
Total number of polymer chains12
Total molecular weight854782.62
Authors
Primary citation
Tuske, S.,Sarafianos, S.G.,Wang, X.,Hudson, B.,Sineva, E.,Mukhopadhyay, J.,Birktoft, J.J.,Leroy, O.,Ismail, S.,Clark, A.D.,Dharia, C.,Napoli, A.,Laptenko, O.,Lee, J.,Borukhov, S.,Ebright, R.H.,Arnold, E.
Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122:541-552, 2005
PubMed: 16122422 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2005.07.017
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers6311.1%13.8%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1zyr
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Molmil generated image of 1zyr
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Molmil generated image of 1zyr
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More Biological unit images

Molmil generated image of 1zyr
no rotation
Molmil generated image of 1zyr
rotated about x axis by 90°
Molmil generated image of 1zyr
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1zyr.pdb1.gz [550.62 KB])
Coordinate files for Biological unit (1zyr.pdb2.gz [552.74 KB])