1P1Y
Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)
Summary for 1P1Y
| Entry DOI | 10.2210/pdb1p1y/pdb |
| Descriptor | 5'-D(*GP*GP*AP*(CBR)P*AP*GP*AP*(BRU)P*GP*GP*GP*AP*G)-3', MAGNESIUM ION (3 entities in total) |
| Functional Keywords | continuous three-dimensional dna lattice, parallel-stranded base pairs, dna |
| Total number of polymer chains | 1 |
| Total formula weight | 4273.76 |
| Authors | Paukstelis, P.J.,Nowakowski, J.,Birktoft, J.J.,Seeman, N.C. (deposition date: 2003-04-14, release date: 2004-06-01, Last modification date: 2024-02-14) |
| Primary citation | Paukstelis, P.J.,Nowakowski, J.,Birktoft, J.J.,Seeman, N.C. Crystal structure of a continuous three-dimensional DNA lattice. Chem.Biol., 11:1119-1126, 2004 Cited by PubMed Abstract: DNA has proved to be a versatile material for the rational design and assembly of nanometer scale objects. Here we report the crystal structure of a continuous three-dimensional DNA lattice formed by the self-assembly of a DNA 13-mer. The structure consists of stacked layers of parallel helices with adjacent layers linked through parallel-stranded base pairing. The hexagonal lattice geometry contains solvent channels that appear large enough to allow 3'-linked guest molecules into the crystal. We have successfully used these parallel base pairs to design and produce crystals with greatly enlarged solvent channels. This lattice may have applications as a molecular scaffold for structure determination of guest molecules, as a molecular sieve, or in the assembly of molecular electronics. Predictable non-Watson-Crick base pairs, like those described here, may present a new tool in structural DNA nanotechnology. PubMed: 15324813DOI: 10.1016/j.chembiol.2004.05.021 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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