1N6Q

HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N)

Summary for 1N6Q

• Entry DOI: 10.2210/pdb1n6q/pdb
• Related: 1N5Y 1RTD
• Descriptor: 5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*AP*(ATM))-3', Reverse Transcriptase, ... (8 entities in total)
• Functional Keywords: drug resistance, hiv, nucleotide excision, reverse transcriptase, complex n, translocation, pre-translocation, transferase-immune system-dna complex, transferase/immune system/dna
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 6
• Total formula weight: 177114.36

Authors

Sarafianos, S.G.,Clark Jr., A.D.,Das, K.,Tuske, S.,Birktoft, J.J.,Ilankumaran, I.,Ramesha, A.R.,Sayer, J.M.,Jerina, D.M.,Boyer, P.L.,Hughes, S.H.,Arnold, E. (deposition date: 2002-11-11, release date: 2003-01-14, Last modification date: 2021-10-27)

• Primary citation: Sarafianos, S.G.,Clark Jr., A.D.,Das, K.,Tuske, S.,Birktoft, J.J.,Ilankumaran, I.,Ramesha, A.R.,Sayer, J.M.,Jerina, D.M.,Boyer, P.L.,Hughes, S.H.,Arnold, E.; Structures of HIV-1 Reverse Transcriptase with Pre- and Post-translocation AZTMP-terminated DNA; Embo J., 21:6614-6624, 2002; PubMed: 12456667; DOI: 10.1093/emboj/cdf637

Experimental method

X-RAY DIFFRACTION (3 Å)