1N6Q

HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (T)	5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'	polymer	27	8367.4	1
2	B (P)	5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*AP*(ATM))-3'	polymer	22	6803.5	1
3	C (A)	Reverse Transcriptase	polymer	558	64249.7	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus 1	HIV-1 RT
4	D (B)	Reverse Transcriptase	polymer	430	50281.8	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus 1	HIV-1 RT
5	E (L)	Monoclonal Antibody (Light Chain)	polymer	211	23362.7	1	Pfam (PF07654) Pfam (PF07686) UniProt (by SIFTS) (I6L991)	Mus musculus (house mouse)
6	F (H)	Monoclonal Antibody (Heavy Chain)	polymer	225	24000.8	1	Pfam (PF07654) UniProt (by SIFTS) (P01868)	Mus musculus (house mouse)
7	G, H (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
8	I (A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 1 - 558 (UniProt: P03366)

PDB	External Database	Details
Cys 258	Gln 425	engineered mutation
Ser 280	Cys 447	engineered mutation

B: 1 - 430 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 447	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	177065.7
Non-Polymers*	Number of molecules	2
	Total formula weight	48.6
All*	Total formula weight	177114.4

*Water molecules are not included.