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3HW4
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CRYSTAL STRUCTURE OF AVIAN INFLUENZA A VIRUS IN COMPLEX WITH TMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z.
Deposit date:2009-06-17
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
3HW5
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CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH AMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Liang, S., Rao, Z.
Deposit date:2009-06-17
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
3HW6
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CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH MN
Descriptor:Polymerase acidic protein, MANGANESE (II) ION
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z.
Deposit date:2009-06-17
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
3QJQ
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THE STRUCTURE OF AND PHOTOLYTIC INDUCED CHANGES OF CARBON MONOXIDE BINDING TO THE CYTOCHROME BA3-OXIDASE FROM THERMUS THERMOPHILUS
Descriptor:Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide 2A, ...
Authors:Liu, B., Zhang, Y., Sage, J.T., Doukov, T., Chen, Y., Stout, C.D., Fee, J.A.
Deposit date:2011-01-30
Release date:2012-01-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural changes that occur upon photolysis of the Fe(II)(a3)-CO complex in the cytochrome ba(3)-oxidase of Thermus thermophilus: A combined X-ray crystallographic and infrared spectral study demonstrates CO binding to Cu(B).
Biochim.Biophys.Acta, 1817, 2012
3QJR
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THE STRUCTURE OF AND PHOTOLYTIC INDUCED CHANGES OF CARBON MONOXIDE BINDING TO THE CYTOCHROME BA3-OXIDASE FROM THERMUS THERMOPHILUS
Descriptor:Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide 2A, ...
Authors:Liu, B., Zhang, Y., Sage, J.T., Doukov, T., Chen, Y., Stout, C.D., Fee, J.A.
Deposit date:2011-01-30
Release date:2012-01-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural changes that occur upon photolysis of the Fe(II)(a3)-CO complex in the cytochrome ba(3)-oxidase of Thermus thermophilus: A combined X-ray crystallographic and infrared spectral study demonstrates CO binding to Cu(B).
Biochim.Biophys.Acta, 1817, 2012
3QJS
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THE STRUCTURE OF AND PHOTOLYTIC INDUCED CHANGES OF CARBON MONOXIDE BINDING TO THE CYTOCHROME BA3-OXIDASE FROM THERMUS THERMOPHILUS
Descriptor:Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide 2A, ...
Authors:Liu, B., Zhang, Y., Sage, J.T., Doukov, T., Chen, Y., Stout, C.D., Fee, J.A.
Deposit date:2011-01-30
Release date:2012-01-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural changes that occur upon photolysis of the Fe(II)(a3)-CO complex in the cytochrome ba(3)-oxidase of Thermus thermophilus: A combined X-ray crystallographic and infrared spectral study demonstrates CO binding to Cu(B).
Biochim.Biophys.Acta, 1817, 2012
3QJT
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THE STRUCTURE OF AND PHOTOLYTIC INDUCED CHANGES OF CARBON MONOXIDE BINDING TO THE CYTOCHROME BA3-OXIDASE FROM THERMUS THERMOPHILUS
Descriptor:Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide 2A, ...
Authors:Liu, B., Zhang, Y., Sage, J.T., Doukov, T., Chen, Y., Stout, C.D., Fee, J.A.
Deposit date:2011-01-30
Release date:2012-01-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural changes that occur upon photolysis of the Fe(II)(a3)-CO complex in the cytochrome ba(3)-oxidase of Thermus thermophilus: A combined X-ray crystallographic and infrared spectral study demonstrates CO binding to Cu(B).
Biochim.Biophys.Acta, 1817, 2012
3QJU
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THE STRUCTURE OF AND PHOTOLYTIC INDUCED CHANGES OF CARBON MONOXIDE BINDING TO THE CYTOCHROME BA3-OXIDASE FROM THERMUS THERMOPHILUS
Descriptor:Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide 2A, ...
Authors:Liu, B., Zhang, Y., Sage, J.T., Doukov, T., Chen, Y., Stout, C.D., Fee, J.A.
Deposit date:2011-01-30
Release date:2012-01-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural changes that occur upon photolysis of the Fe(II)(a3)-CO complex in the cytochrome ba(3)-oxidase of Thermus thermophilus: A combined X-ray crystallographic and infrared spectral study demonstrates CO binding to Cu(B).
Biochim.Biophys.Acta, 1817, 2012
3QJV
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THE STRUCTURE OF AND PHOTOLYTIC INDUCED CHANGES OF CARBON MONOXIDE BINDING TO THE CYTOCHROME BA3-OXIDASE FROM THERMUS THERMOPHILUS
Descriptor:Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide 2A, ...
Authors:Liu, B., Zhang, Y., Sage, J.T., Doukov, T., Chen, Y., Stout, C.D., Fee, J.A.
Deposit date:2011-01-30
Release date:2012-01-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural changes that occur upon photolysis of the Fe(II)(a3)-CO complex in the cytochrome ba(3)-oxidase of Thermus thermophilus: A combined X-ray crystallographic and infrared spectral study demonstrates CO binding to Cu(B).
Biochim.Biophys.Acta, 1817, 2012
3V3E
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CRYSTAL STRUCTURE OF THE HUMAN NUR77 LIGAND-BINDING DOMAIN
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.
Deposit date:2011-12-13
Release date:2012-09-26
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
3V3Q
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CRYSTAL STRUCTURE OF HUMAN NUR77 LIGAND-BINDING DOMAIN IN COMPLEX WITH ETHYL 2-[2,3,4 TRIMETHOXY-6(1-OCTANOYL)PHENYL]ACETATE
Descriptor:Nuclear receptor subfamily 4 group A member 1, ethyl (2,3,4-trimethoxy-6-octanoylphenyl)acetate, GLYCEROL, ...
Authors:Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.
Deposit date:2011-12-14
Release date:2012-09-26
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
4FKZ
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS UDP-GLCNAC 2-EPIMERASE IN COMPLEX WITH UDP-GLCNAC AND UDP
Descriptor:UDP-N-acetylglucosamine 2-epimerase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, URIDINE-5'-DIPHOSPHATE
Authors:Yang, C.S., Chen, S.C., Kuan, S.M., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2012-06-14
Release date:2013-05-08
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal structure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP
To be Published
4IWG
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CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN MJ0927 FROM METHANOCALDOCOCCUS JANNASCHII (IN C2221 FORM)
Descriptor:UPF0135 protein MJ0927
Authors:Kuan, S.M., Chen, S.C., Yang, C.S., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2013-01-23
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.472 Å)
Cite:Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii
To be Published
4IWM
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CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN MJ0927 FROM METHANOCALDOCOCCUS JANNASCHII (IN P21 FORM)
Descriptor:UPF0135 protein MJ0927
Authors:Kuan, S.M., Chen, S.C., Yang, C.S., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2013-01-24
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii
To be Published
4IXA
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STRUCTURE OF DNA-BINDING DOMAIN OF THE RESPONSE REGULATOR SAER FROM STAPHYLOCOCCUS EPIDERMIDIS
Descriptor:Response regulator SaeR
Authors:Chen, Y.R., Chen, S.C., Yang, C.S., Kuan, S.M., Liu, Y.H., Chen, Y.
Deposit date:2013-01-24
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus epidermidis
To be Published
4JIS
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CRYSTAL STRUCTURE OF RIBITOL 5-PHOSPHATE CYTIDYLYLTRANSFERASE (TARI) FROM BACILLUS SUBTILIS
Descriptor:ribitol-5-phosphate cytidylyltransferase
Authors:Yang, C.S., Chen, S.C., Chen, Y.R., Kuan, S.M., Liu, Y.H., Chen, Y.
Deposit date:2013-03-06
Release date:2014-03-12
Method:X-RAY DIFFRACTION (1.772 Å)
Cite:Crystal structure of ribitol 5-phosphate cytidylyltransferase (TarI) from Bacillus subtilis
To be Published
4Q2W
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL PEPTIDOGLYCAN HYDROLASE LYTB
Descriptor:Putative endo-beta-N-acetylglucosaminidase, GLYCEROL
Authors:Bai, X.H., Chen, H.J., Jiang, Y.L., Wen, Z., Cheng, W., Li, Q., Zhang, J.R., Chen, Y., Zhou, C.Z.
Deposit date:2014-04-10
Release date:2014-07-16
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis.
J.Biol.Chem., 289, 2014
5JKG
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THE CRYSTAL STRUCTURE OF FGFR4 KINASE DOMAIN IN COMPLEX WITH LY2874455
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, L., Chen, Y.
Deposit date:2016-04-26
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
Plos One, 11, 2016
6AKO
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CRYSTAL STRUCTURE OF FOXC2 DBD BOUND TO DBE2 DNA
Descriptor:DNA (5'-D(CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Forkhead box protein C2, ...
Authors:Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
Deposit date:2018-09-03
Release date:2019-02-06
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 47, 2019
6AKP
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CRYSTAL STRUCTURAL OF FOXC2 DNA BINDING DOMAIN BOUND TO PC PROMOTER
Descriptor:DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION
Authors:Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
Deposit date:2018-09-03
Release date:2019-02-06
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 47, 2019
6JJ3
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BRD4 IN COMPLEX WITH 138A
Descriptor:Bromodomain-containing protein 4, 2-methoxy-N-[2-methyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]benzenesulfonamide
Authors:Xu, J., Chen, Y., Jiang, F., Zhu, J.
Deposit date:2019-02-25
Release date:2020-01-22
Method:X-RAY DIFFRACTION (1.718 Å)
Cite:Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.
J.Med.Chem., 62, 2019
6JJB
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BRD4 IN COMPLEX WITH ZZM1
Descriptor:Bromodomain-containing protein 4, 2-methoxy-N-(1-methyl-2-oxidanylidene-benzo[cd]indol-6-yl)benzenesulfonamide
Authors:Xu, J., Chen, Y., Jiang, F., Zhu, J.
Deposit date:2019-02-25
Release date:2020-01-22
Method:X-RAY DIFFRACTION (1.508 Å)
Cite:Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.
J.Med.Chem., 62, 2019
6JPE
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CRYSTAL STRUCTURE OF FGFR4 KINASE DOMAIN WITH IRREVERSIBLE INHIBITOR 1
Descriptor:Fibroblast growth factor receptor 4, N-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide, SULFATE ION
Authors:Chen, X., Dai, S., Zhou, Z., Chen, Y.
Deposit date:2019-03-26
Release date:2020-05-06
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Development and Preclinical Characterization of Exquisitely Specific FGFR4 Inhibitors
To Be Published
5BND
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF TAGH
Descriptor:ABC transporter, ATP-binding protein
Authors:Chen, S.C., Chen, Y.
Deposit date:2015-05-26
Release date:2016-07-06
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:SH3-Like Motif-Containing C-terminal Domain of Staphylococcal Teichoic Acid Transporter Suggests Possible Function.
Proteins, 2016
6J07
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CRYSTAL STRUCTURE OF HUMAN TERB2 AND TERB1
Descriptor:Telomere repeats-binding bouquet formation protein 2, Telomere repeats-binding bouquet formation protein 1, ZINC ION
Authors:Wang, Y., Chen, Y., Wu, J., Huang, C., Lei, M.
Deposit date:2018-12-21
Release date:2019-02-27
Method:X-RAY DIFFRACTION (3.298 Å)
Cite:The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
169117
数据于2020-09-23公开中