7FJD

Cryo-EM structure of a membrane protein(WT)

Summary for 7FJD

• Entry DOI: 10.2210/pdb7fjd/pdb
• EMDB information: 31618
• Descriptor: T-cell surface glycoprotein CD3 zeta chain, T-cell surface glycoprotein CD3 delta chain, T-cell surface glycoprotein CD3 epsilon chain, ... (7 entities in total)
• Functional Keywords: membrane, immune, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 189563.56

Authors

Chen, Y.,Zhu, Y.,Gao, W.,Zhang, A.,Guo, C.,Huang, Z. (deposition date: 2021-08-03, release date: 2022-07-27)

• Primary citation: Chen, Y.,Zhu, Y.,Li, X.,Gao, W.,Zhen, Z.,Huang, B.,Ma, Z.,Zhang, A.,Song, X.,Ma, Y.,Guo, C.,Zhang, F.,Huang, Z.; Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.; Mol.Cell, 82:1278-1287.e5, 2022; PubMed: 35271814; DOI: 10.1016/j.molcel.2022.02.017

Experimental method

ELECTRON MICROSCOPY (3.2 Å)