Author results

5XFJ
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CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550M)
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, Y.
Deposit date:2017-04-10
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
5XP5
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C-SRC IN COMPLEX WITH ATP-CHF
Descriptor:Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid, MAGNESIUM ION
Authors:Duan, Y., Guo, M., Dai, S., Chen, L., Chen, Y.
Deposit date:2017-06-01
Release date:2018-02-07
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
5XP7
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C-SRC IN COMPLEX WITH ATP-CHCL
Descriptor:Proto-oncogene tyrosine-protein kinase Src, [(R)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]-chloranyl-methyl]phosphonic acid, MAGNESIUM ION, ...
Authors:Guo, M., Dai, S., Duan, Y., Chen, L., Chen, Y.
Deposit date:2017-06-01
Release date:2017-09-06
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.012 Å)
Cite:Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
5YRP
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CRYSTAL STRUCTURE OF THE EAL DOMAIN OF MYCOBACTERIUM SMEGMATIS DCPA
Descriptor:Sensory box/response regulator, MAGNESIUM ION
Authors:Chen, H.J., li, N., Luo, Y., Jiang, Y.L., Zhou, C.Z., Chen, Y., Li, Q.
Deposit date:2017-11-09
Release date:2018-05-09
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP inMycobacterium smegmatis.
Biochem. J., 475, 2018
6IF8
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AEROMONAS HYDROPHILA MTAN-2 COMPLEXED WITH ADENINE
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE
Authors:Chen, J., Liu, W., Wang, L., Shang, F., Lan, J., Chen, Y., Xu, Y.
Deposit date:2018-09-18
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Aeromonas hydrophila MtaN-2 complexed with adenine
To Be Published
6K2Q
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AEROMONAS HYDROPHILA MTAN-2 COMPLEXED WITH ADENINE
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE
Authors:Chen, J., Liu, W., Wang, L., Shang, F., Lan, J., Chen, Y., Xu, Y.
Deposit date:2019-05-15
Release date:2019-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Aeromonas hydrophila MtaN-2 complexed with adenine
To Be Published
3V3E
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CRYSTAL STRUCTURE OF THE HUMAN NUR77 LIGAND-BINDING DOMAIN
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.
Deposit date:2011-12-13
Release date:2012-09-26
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
3V3Q
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CRYSTAL STRUCTURE OF HUMAN NUR77 LIGAND-BINDING DOMAIN IN COMPLEX WITH ETHYL 2-[2,3,4 TRIMETHOXY-6(1-OCTANOYL)PHENYL]ACETATE
Descriptor:Nuclear receptor subfamily 4 group A member 1, ethyl (2,3,4-trimethoxy-6-octanoylphenyl)acetate, GLYCEROL, ...
Authors:Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.
Deposit date:2011-12-14
Release date:2012-09-26
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
4FKZ
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS UDP-GLCNAC 2-EPIMERASE IN COMPLEX WITH UDP-GLCNAC AND UDP
Descriptor:UDP-N-acetylglucosamine 2-epimerase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, URIDINE-5'-DIPHOSPHATE
Authors:Yang, C.S., Chen, S.C., Kuan, S.M., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2012-06-14
Release date:2013-05-08
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal structure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP
To be Published
4IWG
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CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN MJ0927 FROM METHANOCALDOCOCCUS JANNASCHII (IN C2221 FORM)
Descriptor:UPF0135 protein MJ0927
Authors:Kuan, S.M., Chen, S.C., Yang, C.S., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2013-01-23
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.472 Å)
Cite:Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii
To be Published
4IWM
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CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN MJ0927 FROM METHANOCALDOCOCCUS JANNASCHII (IN P21 FORM)
Descriptor:UPF0135 protein MJ0927
Authors:Kuan, S.M., Chen, S.C., Yang, C.S., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2013-01-24
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii
To be Published
4IXA
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STRUCTURE OF DNA-BINDING DOMAIN OF THE RESPONSE REGULATOR SAER FROM STAPHYLOCOCCUS EPIDERMIDIS
Descriptor:Response regulator SaeR
Authors:Chen, Y.R., Chen, S.C., Yang, C.S., Kuan, S.M., Liu, Y.H., Chen, Y.
Deposit date:2013-01-24
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus epidermidis
To be Published
4JIS
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CRYSTAL STRUCTURE OF RIBITOL 5-PHOSPHATE CYTIDYLYLTRANSFERASE (TARI) FROM BACILLUS SUBTILIS
Descriptor:ribitol-5-phosphate cytidylyltransferase
Authors:Yang, C.S., Chen, S.C., Chen, Y.R., Kuan, S.M., Liu, Y.H., Chen, Y.
Deposit date:2013-03-06
Release date:2014-03-12
Method:X-RAY DIFFRACTION (1.772 Å)
Cite:Crystal structure of ribitol 5-phosphate cytidylyltransferase (TarI) from Bacillus subtilis
To be Published
4Q2W
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CRYSTAL STRUCTURE OF PNEUMOCOCCAL PEPTIDOGLYCAN HYDROLASE LYTB
Descriptor:Putative endo-beta-N-acetylglucosaminidase, GLYCEROL
Authors:Bai, X.H., Chen, H.J., Jiang, Y.L., Wen, Z., Cheng, W., Li, Q., Zhang, J.R., Chen, Y., Zhou, C.Z.
Deposit date:2014-04-10
Release date:2014-07-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis
J.Biol.Chem., 2014
5F59
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THE CRYSTAL STRUCTURE OF MLL3 SET DOMAIN
Descriptor:Histone-lysine N-methyltransferase 2C, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F5E
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THE CRYSTAL STRUCTURE OF MLL1 SET DOMAIN WITH N3816I/Q3867L MUTATION
Descriptor:Histone-lysine N-methyltransferase 2A, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6K
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CRYSTAL STRUCTURE OF THE MLL3-ASH2L-RBBP5 COMPLEX
Descriptor:Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ...
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-06
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.411 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6L
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THE CRYSTAL STRUCTURE OF MLL1 (N3861I/Q3867L) IN COMPLEX WITH RBBP5 AND ASH2L
Descriptor:Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, ...
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-06
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5JKG
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THE CRYSTAL STRUCTURE OF FGFR4 KINASE DOMAIN IN COMPLEX WITH LY2874455
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, L., Chen, Y.
Deposit date:2016-04-26
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
Plos One, 11, 2016
6AKO
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CRYSTAL STRUCTURE OF FOXC2 DBD BOUND TO DBE2 DNA
Descriptor:DNA (5'-D(CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Forkhead box protein C2, ...
Authors:Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
Deposit date:2018-09-03
Release date:2019-02-06
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 47, 2019
6AKP
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CRYSTAL STRUCTURAL OF FOXC2 DNA BINDING DOMAIN BOUND TO PC PROMOTER
Descriptor:DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION
Authors:Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y.
Deposit date:2018-09-03
Release date:2019-02-06
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.323 Å)
Cite:Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 47, 2019
1P2A
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THE STRUCTURE OF CYCLIN DEPENDENT KINASE 2 (CKD2) WITH A TRISUBSTITUTED NAPHTHOSTYRIL INHIBITOR
Descriptor:Cell division protein kinase 2, 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE
Authors:Liu, J.-J., Dermatakis, A., Lukacs, C.M., Konzelmann, F., Chen, Y., Kammlott, U., Depinto, W., Yang, H., Yin, X., Chen, Y., Schutt, A., Simcox, M.E., Luk, K.-C.
Deposit date:2003-04-15
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors
BIOORG.MED.CHEM., 13, 2003
3HW3
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THE CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH UMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, URIDINE-5'-MONOPHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z.
Deposit date:2009-06-17
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
3HW4
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CRYSTAL STRUCTURE OF AVIAN INFLUENZA A VIRUS IN COMPLEX WITH TMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z.
Deposit date:2009-06-17
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
3HW5
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CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH AMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Liang, S., Rao, Z.
Deposit date:2009-06-17
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009