5XFJ | | CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550M) | | Descriptor: | Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol | | Authors: | Wu, D., Chen, Y. | | Deposit date: | 2017-04-10 | | Release date: | 2018-08-08 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
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5XP5 | | C-SRC IN COMPLEX WITH ATP-CHF | | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid, MAGNESIUM ION | | Authors: | Duan, Y., Guo, M., Dai, S., Chen, L., Chen, Y. | | Deposit date: | 2017-06-01 | | Release date: | 2018-02-07 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
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5XP7 | | C-SRC IN COMPLEX WITH ATP-CHCL | | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, [(R)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]-chloranyl-methyl]phosphonic acid, MAGNESIUM ION, ... | | Authors: | Guo, M., Dai, S., Duan, Y., Chen, L., Chen, Y. | | Deposit date: | 2017-06-01 | | Release date: | 2017-09-06 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.012 Å) | | Cite: | Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
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5YRP | | CRYSTAL STRUCTURE OF THE EAL DOMAIN OF MYCOBACTERIUM SMEGMATIS DCPA | | Descriptor: | Sensory box/response regulator, MAGNESIUM ION | | Authors: | Chen, H.J., li, N., Luo, Y., Jiang, Y.L., Zhou, C.Z., Chen, Y., Li, Q. | | Deposit date: | 2017-11-09 | | Release date: | 2018-05-09 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP inMycobacterium smegmatis.
Biochem. J., 475, 2018
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6IF8 | | AEROMONAS HYDROPHILA MTAN-2 COMPLEXED WITH ADENINE | | Descriptor: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE | | Authors: | Chen, J., Liu, W., Wang, L., Shang, F., Lan, J., Chen, Y., Xu, Y. | | Deposit date: | 2018-09-18 | | Release date: | 2018-10-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Aeromonas hydrophila MtaN-2 complexed with adenine
To Be Published
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6K2Q | | AEROMONAS HYDROPHILA MTAN-2 COMPLEXED WITH ADENINE | | Descriptor: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE | | Authors: | Chen, J., Liu, W., Wang, L., Shang, F., Lan, J., Chen, Y., Xu, Y. | | Deposit date: | 2019-05-15 | | Release date: | 2019-05-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Aeromonas hydrophila MtaN-2 complexed with adenine
To Be Published
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3V3E | | CRYSTAL STRUCTURE OF THE HUMAN NUR77 LIGAND-BINDING DOMAIN | | Descriptor: | Nuclear receptor subfamily 4 group A member 1, GLYCEROL | | Authors: | Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T. | | Deposit date: | 2011-12-13 | | Release date: | 2012-09-26 | | Last modified: | 2013-07-10 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
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3V3Q | | CRYSTAL STRUCTURE OF HUMAN NUR77 LIGAND-BINDING DOMAIN IN COMPLEX WITH ETHYL 2-[2,3,4 TRIMETHOXY-6(1-OCTANOYL)PHENYL]ACETATE | | Descriptor: | Nuclear receptor subfamily 4 group A member 1, ethyl (2,3,4-trimethoxy-6-octanoylphenyl)acetate, GLYCEROL, ... | | Authors: | Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T. | | Deposit date: | 2011-12-14 | | Release date: | 2012-09-26 | | Last modified: | 2013-07-10 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
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4FKZ | | CRYSTAL STRUCTURE OF BACILLUS SUBTILIS UDP-GLCNAC 2-EPIMERASE IN COMPLEX WITH UDP-GLCNAC AND UDP | | Descriptor: | UDP-N-acetylglucosamine 2-epimerase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, URIDINE-5'-DIPHOSPHATE | | Authors: | Yang, C.S., Chen, S.C., Kuan, S.M., Chen, Y.R., Liu, Y.H., Chen, Y. | | Deposit date: | 2012-06-14 | | Release date: | 2013-05-08 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Crystal structure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP
To be Published
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4IWG | | CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN MJ0927 FROM METHANOCALDOCOCCUS JANNASCHII (IN C2221 FORM) | | Descriptor: | UPF0135 protein MJ0927 | | Authors: | Kuan, S.M., Chen, S.C., Yang, C.S., Chen, Y.R., Liu, Y.H., Chen, Y. | | Deposit date: | 2013-01-23 | | Release date: | 2014-01-29 | | Method: | X-RAY DIFFRACTION (2.472 Å) | | Cite: | Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii
To be Published
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4IWM | | CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN MJ0927 FROM METHANOCALDOCOCCUS JANNASCHII (IN P21 FORM) | | Descriptor: | UPF0135 protein MJ0927 | | Authors: | Kuan, S.M., Chen, S.C., Yang, C.S., Chen, Y.R., Liu, Y.H., Chen, Y. | | Deposit date: | 2013-01-24 | | Release date: | 2014-01-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii
To be Published
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4IXA | | STRUCTURE OF DNA-BINDING DOMAIN OF THE RESPONSE REGULATOR SAER FROM STAPHYLOCOCCUS EPIDERMIDIS | | Descriptor: | Response regulator SaeR | | Authors: | Chen, Y.R., Chen, S.C., Yang, C.S., Kuan, S.M., Liu, Y.H., Chen, Y. | | Deposit date: | 2013-01-24 | | Release date: | 2014-01-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus epidermidis
To be Published
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4JIS | | CRYSTAL STRUCTURE OF RIBITOL 5-PHOSPHATE CYTIDYLYLTRANSFERASE (TARI) FROM BACILLUS SUBTILIS | | Descriptor: | ribitol-5-phosphate cytidylyltransferase | | Authors: | Yang, C.S., Chen, S.C., Chen, Y.R., Kuan, S.M., Liu, Y.H., Chen, Y. | | Deposit date: | 2013-03-06 | | Release date: | 2014-03-12 | | Method: | X-RAY DIFFRACTION (1.772 Å) | | Cite: | Crystal structure of ribitol 5-phosphate cytidylyltransferase (TarI) from Bacillus subtilis
To be Published
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4Q2W | | CRYSTAL STRUCTURE OF PNEUMOCOCCAL PEPTIDOGLYCAN HYDROLASE LYTB | | Descriptor: | Putative endo-beta-N-acetylglucosaminidase, GLYCEROL | | Authors: | Bai, X.H., Chen, H.J., Jiang, Y.L., Wen, Z., Cheng, W., Li, Q., Zhang, J.R., Chen, Y., Zhou, C.Z. | | Deposit date: | 2014-04-10 | | Release date: | 2014-07-16 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis
J.Biol.Chem., 2014
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5F59 | | THE CRYSTAL STRUCTURE OF MLL3 SET DOMAIN | | Descriptor: | Histone-lysine N-methyltransferase 2C, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Li, Y., Lei, M., Chen, Y. | | Deposit date: | 2015-12-04 | | Release date: | 2016-02-24 | | Last modified: | 2016-04-20 | | Method: | X-RAY DIFFRACTION (2.801 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
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5F5E | |
5F6K | | CRYSTAL STRUCTURE OF THE MLL3-ASH2L-RBBP5 COMPLEX | | Descriptor: | Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ... | | Authors: | Li, Y., Lei, M., Chen, Y. | | Deposit date: | 2015-12-06 | | Release date: | 2016-02-24 | | Last modified: | 2016-04-20 | | Method: | X-RAY DIFFRACTION (2.411 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
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5F6L | | THE CRYSTAL STRUCTURE OF MLL1 (N3861I/Q3867L) IN COMPLEX WITH RBBP5 AND ASH2L | | Descriptor: | Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, ... | | Authors: | Li, Y., Lei, M., Chen, Y. | | Deposit date: | 2015-12-06 | | Release date: | 2016-02-24 | | Last modified: | 2016-04-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
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5JKG | | THE CRYSTAL STRUCTURE OF FGFR4 KINASE DOMAIN IN COMPLEX WITH LY2874455 | | Descriptor: | Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol | | Authors: | Wu, D., Chen, L., Chen, Y. | | Deposit date: | 2016-04-26 | | Release date: | 2016-10-05 | | Method: | X-RAY DIFFRACTION (2.352 Å) | | Cite: | Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
Plos One, 11, 2016
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6AKO | | CRYSTAL STRUCTURE OF FOXC2 DBD BOUND TO DBE2 DNA | | Descriptor: | DNA (5'-D(CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Forkhead box protein C2, ... | | Authors: | Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y. | | Deposit date: | 2018-09-03 | | Release date: | 2019-02-06 | | Last modified: | 2019-05-01 | | Method: | X-RAY DIFFRACTION (2.396 Å) | | Cite: | Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 47, 2019
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6AKP | | CRYSTAL STRUCTURAL OF FOXC2 DNA BINDING DOMAIN BOUND TO PC PROMOTER | | Descriptor: | DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION | | Authors: | Chen, X., Wei, H., Li, J., Liang, X., Dai, S., Jiang, L., Guo, M., Chen, Y. | | Deposit date: | 2018-09-03 | | Release date: | 2019-02-06 | | Last modified: | 2019-05-01 | | Method: | X-RAY DIFFRACTION (2.323 Å) | | Cite: | Structural basis for DNA recognition by FOXC2.
Nucleic Acids Res., 47, 2019
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1P2A | | THE STRUCTURE OF CYCLIN DEPENDENT KINASE 2 (CKD2) WITH A TRISUBSTITUTED NAPHTHOSTYRIL INHIBITOR | | Descriptor: | Cell division protein kinase 2, 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE | | Authors: | Liu, J.-J., Dermatakis, A., Lukacs, C.M., Konzelmann, F., Chen, Y., Kammlott, U., Depinto, W., Yang, H., Yin, X., Chen, Y., Schutt, A., Simcox, M.E., Luk, K.-C. | | Deposit date: | 2003-04-15 | | Release date: | 2003-07-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | 3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors
BIOORG.MED.CHEM., 13, 2003
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3HW3 | | THE CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH UMP | | Descriptor: | Polymerase acidic protein, MAGNESIUM ION, URIDINE-5'-MONOPHOSPHATE | | Authors: | Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z. | | Deposit date: | 2009-06-17 | | Release date: | 2009-10-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
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3HW4 | | CRYSTAL STRUCTURE OF AVIAN INFLUENZA A VIRUS IN COMPLEX WITH TMP | | Descriptor: | Polymerase acidic protein, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE | | Authors: | Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z. | | Deposit date: | 2009-06-17 | | Release date: | 2009-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
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3HW5 | | CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH AMP | | Descriptor: | Polymerase acidic protein, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE | | Authors: | Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Liang, S., Rao, Z. | | Deposit date: | 2009-06-17 | | Release date: | 2009-10-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
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