Author results

5XFF
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CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550L)
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, Y.
Deposit date:2017-04-10
Release date:2018-09-05
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
5XFJ
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CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550M)
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, Y.
Deposit date:2017-04-10
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
2LJV
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SOLUTION STRUCTURE OF RHODOSTOMIN G50L MUTANT
Descriptor:Disintegrin rhodostomin
Authors:Chuang, W., Shiu, J., Chen, C., Chen, Y., Chang, Y., Huang, C.
Deposit date:2011-09-29
Release date:2012-10-03
Method:SOLUTION NMR
Cite:Design of Integrin AlphaVbeta3-Specific Disintegrin for Cancer Therapy
To be Published
2O14
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X-RAY CRYSTAL STRUCTURE OF PROTEIN YXIM_BACSU FROM BACILLUS SUBTILIS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR595
Descriptor:Hypothetical protein yxiM, MANGANESE (II) ION, SULFATE ION
Authors:Kuzin, A.P., Chen, Y., Seetharaman, J., Chen, C.X., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-11-28
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray structure of the hypothetical protein YXIM_BACsu from Bacillus subtilis.
To be Published
2QGU
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THREE-DIMENSIONAL STRUCTURE OF THE PHOSPHOLIPID-BINDING PROTEIN FROM RALSTONIA SOLANACEARUM Q8XV73_RALSQ IN COMPLEX WITH A PHOSPHOLIPID AT THE RESOLUTION 1.53 A. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RSR89
Descriptor:Probable signal peptide protein, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE
Authors:Kuzin, A.P., Chen, Y., Jayaraman, S., Chen, C.X., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-06-29
Release date:2007-07-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structure of the phospholipid-binding protein from Ralstonia solanacearum Q8XV73_RALSQ in complex with a phospholipid at the resolution 1.53 A.
To be Published
3QRF
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STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER
Descriptor:Nuclear factor of activated T-cells, cytoplasmic 2, Forkhead box protein P3, ...
Authors:Bandukwala, H.S., Wu, Y., Feurer, M., Chen, Y., Barbosa, B., Ghosh, S., Stroud, J.C., Benoist, C., Mathis, D., Rao, A., Chen, L.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34, 2011
4EPK
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EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, ZINC ION, MAGNESIUM ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-17
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.6009 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
4ERA
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EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, COBALT (II) ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-19
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
4ERG
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EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, FE (III) ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-20
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
4ERI
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EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, ZINC ION, MAGNESIUM ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-20
Release date:2012-08-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.0006 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
4KYH
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH ZOPOLRESTAT
Descriptor:Lactoylglutathione lyase, ZINC ION, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
4KYK
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH INDOMETHACIN
Descriptor:Lactoylglutathione lyase, ZINC ION, INDOMETHACIN
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
5F2E
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-853 COVALENTLY BOUND TO K-RAS G12C
Descriptor:GTPase KRas, MAGNESIUM ION, GLYCEROL, ...
Authors:Patricelli, M.P., Janes, M.R., Li, L.-S., Hansen, R., Peters, U., Kessler, L.V., Chen, Y., Kucharski, J.M., Feng, J., Ely, T., Chen, J.H., Firdaus, S.J., Babbar, A., Ren, P., Liu, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.
Cancer Discov, 6, 2016
5F59
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THE CRYSTAL STRUCTURE OF MLL3 SET DOMAIN
Descriptor:Histone-lysine N-methyltransferase 2C, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F5E
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THE CRYSTAL STRUCTURE OF MLL1 SET DOMAIN WITH N3816I/Q3867L MUTATION
Descriptor:Histone-lysine N-methyltransferase 2A, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6K
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CRYSTAL STRUCTURE OF THE MLL3-ASH2L-RBBP5 COMPLEX
Descriptor:Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ...
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-06
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.411 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5F6L
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THE CRYSTAL STRUCTURE OF MLL1 (N3861I/Q3867L) IN COMPLEX WITH RBBP5 AND ASH2L
Descriptor:Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, ...
Authors:Li, Y., Lei, M., Chen, Y.
Deposit date:2015-12-06
Release date:2016-02-24
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for activity regulation of MLL family methyltransferases.
Nature, 530, 2016
5XP5
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C-SRC IN COMPLEX WITH ATP-CHF
Descriptor:Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid, MAGNESIUM ION
Authors:Duan, Y., Guo, M., Dai, S., Chen, L., Chen, Y.
Deposit date:2017-06-01
Release date:2018-02-07
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
5XP7
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C-SRC IN COMPLEX WITH ATP-CHCL
Descriptor:Proto-oncogene tyrosine-protein kinase Src, [(R)-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]-chloranyl-methyl]phosphonic acid, MAGNESIUM ION, ...
Authors:Guo, M., Dai, S., Duan, Y., Chen, L., Chen, Y.
Deposit date:2017-06-01
Release date:2017-09-06
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.012 Å)
Cite:Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
5YRP
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CRYSTAL STRUCTURE OF THE EAL DOMAIN OF MYCOBACTERIUM SMEGMATIS DCPA
Descriptor:Sensory box/response regulator, MAGNESIUM ION
Authors:Chen, H.J., li, N., Luo, Y., Jiang, Y.L., Zhou, C.Z., Chen, Y., Li, Q.
Deposit date:2017-11-09
Release date:2018-05-09
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP inMycobacterium smegmatis.
Biochem. J., 475, 2018
6IF8
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AEROMONAS HYDROPHILA MTAN-2 COMPLEXED WITH ADENINE
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE
Authors:Chen, J., Liu, W., Wang, L., Shang, F., Lan, J., Chen, Y., Xu, Y.
Deposit date:2018-09-18
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Aeromonas hydrophila MtaN-2 complexed with adenine
To Be Published
6K2Q
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AEROMONAS HYDROPHILA MTAN-2 COMPLEXED WITH ADENINE
Descriptor:5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE
Authors:Chen, J., Liu, W., Wang, L., Shang, F., Lan, J., Chen, Y., Xu, Y.
Deposit date:2019-05-15
Release date:2019-05-29
Last modified:2020-06-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Aeromonas hydrophila Cytoplasmic 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase.
Biochemistry, 58, 2019
6L2W
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CRYSTAL STRUCTURE OF A NOVEL FOLD PROTEIN GP72 FROM THE FRESHWATER CYANOPHAGE MIC1
Descriptor:freshwater cyanophage protein
Authors:Wang, Y., Jin, H., Yang, F., Jiang, Y.L., Zhao, Y.Y., Chen, Z.P., Li, W.F., Chen, Y., Zhou, C.Z., Li, Q.
Deposit date:2019-10-07
Release date:2020-05-13
Last modified:2020-08-12
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal structure of a novel fold protein Gp72 from the freshwater cyanophage Mic1.
Proteins, 88, 2020
1P2A
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THE STRUCTURE OF CYCLIN DEPENDENT KINASE 2 (CKD2) WITH A TRISUBSTITUTED NAPHTHOSTYRIL INHIBITOR
Descriptor:Cell division protein kinase 2, 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE
Authors:Liu, J.-J., Dermatakis, A., Lukacs, C.M., Konzelmann, F., Chen, Y., Kammlott, U., Depinto, W., Yang, H., Yin, X., Chen, Y., Schutt, A., Simcox, M.E., Luk, K.-C.
Deposit date:2003-04-15
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors
BIOORG.MED.CHEM., 13, 2003
3HW3
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THE CRYSTAL STRUCTURE OF AVIAN INFLUENZA VIRUS PA_N IN COMPLEX WITH UMP
Descriptor:Polymerase acidic protein, MAGNESIUM ION, URIDINE-5'-MONOPHOSPHATE
Authors:Zhao, C., Lou, Z., Guo, Y., Ma, M., Chen, Y., Rao, Z.
Deposit date:2009-06-17
Release date:2009-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
J.Virol., 83, 2009
168889
数据于2020-09-16公开中