Author results

2N7X
  • Download 2n7x
  • View 2n7x
Molmil generated image of 2n7x
SOLUTION STRUCTURE OF MICRORNA 20B PRE-ELEMENT
Descriptor:RNA (5'-R(*GP*GP*UP*AP*GP*UP*UP*UP*UP*GP*GP*CP*AP*UP*GP*AP*CP*UP*CP*UP*AP*CP*C)-3')
Authors:Yang, F., Chen, Y., Varani, G.
Deposit date:2015-09-25
Release date:2016-04-13
Last modified:2016-06-01
Method:SOLUTION NMR
Cite:Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.
Nucleic Acids Res., 44, 2016
2N82
  • Download 2n82
  • View 2n82
Molmil generated image of 2n82
SOLUTION STRUCTURE OF THE COMPLEX OF MICRORNA 20B PRE-ELEMENT WITH RBFOX RRM
Descriptor:RNA (5'-R(*GP*GP*UP*AP*GP*UP*UP*UP*UP*GP*GP*CP*AP*UP*GP*AP*CP*UP*CP*UP*AP*CP*C)-3'), RNA binding protein fox-1 homolog 1
Authors:Yang, F., Chen, Y., Varani, G.
Deposit date:2015-09-30
Release date:2016-04-13
Last modified:2016-06-01
Method:SOLUTION NMR
Cite:Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.
Nucleic Acids Res., 44, 2016
3DB1
  • Download 3db1
  • View 3db1
Molmil generated image of 3db1
CRYSTAL STRUCTURE OF THE 2H-PHOSPHATASE DOMAIN OF STS-2 IN COMPLEX WITH PHOSPHATE
Descriptor:STS-2 protein, PHOSPHATE ION
Authors:Nassar, N., Chen, Y., Carpino, N.
Deposit date:2008-05-30
Release date:2009-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural and functional characterization of the 2H-phosphatase domain of Sts-2 reveals an acid-dependent phosphatase activity.
Biochemistry, 48, 2009
3P2T
  • Download 3p2t
  • View 3p2t
Molmil generated image of 3p2t
CRYSTAL STRUCTURE OF LEUKOCYTE IG-LIKE RECEPTOR LILRB4 (ILT3/LIR-5/CD85K)
Descriptor:Leukocyte immunoglobulin-like receptor subfamily B member 4, SULFATE ION
Authors:Chen, Y., Nam, G., Cheng, H., Zhang, J.H., Willcox, B.E., Gao, G.F.
Deposit date:2010-10-04
Release date:2011-03-30
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance
J.Biol.Chem., 286, 2011
3VAR
  • Download 3var
  • View 3var
Molmil generated image of 3var
CRYSTAL STRUCTURE OF DNPEP, ZNZN FORM
Descriptor:Aspartyl aminopeptidase, ZINC ION
Authors:Kiser, P.D., Chen, Y., Palczewski, K.
Deposit date:2011-12-29
Release date:2012-02-29
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insights into substrate specificity and metal activation of Mammalian tetrahedral aspartyl aminopeptidase.
J.Biol.Chem., 287, 2012
3VAT
  • Download 3vat
  • View 3vat
Molmil generated image of 3vat
CRYSTAL STRUCTURE OF DNPEP, ZNMG FORM
Descriptor:Aspartyl aminopeptidase, ZINC ION, MAGNESIUM ION
Authors:Kiser, P.D., Chen, Y., Palczewski, K.
Deposit date:2011-12-29
Release date:2012-02-29
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights into substrate specificity and metal activation of Mammalian tetrahedral aspartyl aminopeptidase.
J.Biol.Chem., 287, 2012
4C0E
  • Download 4c0e
  • View 4c0e
Molmil generated image of 4c0e
STRUCTURE OF THE NOT1 SUPERFAMILY HOMOLOGY DOMAIN FROM CHAETOMIUM THERMOPHILUM
Descriptor:NOT1
Authors:Chen, Y., Boland, A., Raisch, T., Jonas, S., Izaurralde, E., Weichenrieder, O.
Deposit date:2013-08-01
Release date:2013-10-09
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and Assembly of the not Module of the Human Ccr4-not Complex
Nat.Struct.Mol.Biol., 20, 2013
4CRV
  • Download 4crv
  • View 4crv
Molmil generated image of 4crv
COMPLEX OF HUMAN CNOT9 AND CNOT1 INCLUDING TWO TRYPTOPHANS
Descriptor:CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CELL DIFFERENTIATION PROTEIN RCD1 HOMOLOG, TRYPTOPHAN, ...
Authors:Boland, A., Chen, Y., Izaurralde, E., Weichenrieder, O.
Deposit date:2014-03-01
Release date:2014-05-07
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing
Mol.Cell, 54, 2014
4IIK
  • Download 4iik
  • View 4iik
Molmil generated image of 4iik
LEGIONELLA PNEUMOPHILA EFFECTOR
Descriptor:Adenosine monophosphate-protein hydrolase SidD, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Tascon, I., Chen, Y., Neunuebel, M.R., Rojas, A.L., Machner, M.P., Hierro, A.
Deposit date:2012-12-20
Release date:2013-06-19
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD
Plos Pathog., 9, 2013
4IIP
  • Download 4iip
  • View 4iip
Molmil generated image of 4iip
LEGIONELLA PNEUMOPHILA EFFECTOR
Descriptor:Adenosine monophosphate-protein hydrolase SidD, GLYCEROL, CHLORIDE ION
Authors:Tascon, I., Chen, Y., Neunuebel, M.R., Rojas, A.L., Machner, M.P., Hierro, A.
Deposit date:2012-12-20
Release date:2013-06-19
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD
Plos Pathog., 9, 2013
5SY1
  • Download 5sy1
  • View 5sy1
Molmil generated image of 5sy1
STRUCTURE OF THE STRA6 RECEPTOR FOR RETINOL UPTAKE IN COMPLEX WITH CALMODULIN
Descriptor:Calmodulin, STRA6, CALCIUM ION, ...
Authors:Clarke, O.B., Chen, Y., Mancia, F.
Deposit date:2016-08-10
Release date:2016-08-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the STRA6 receptor for retinol uptake.
Science, 353, 2016
6UEC
  • Download 6uec
  • View 6uec
Molmil generated image of 6uec
PSEUDOMONAS AERUGINOSA LPXD COMPLEX STRUCTURE WITH LIGAND
Descriptor:UDP-3-O-acylglucosamine N-acyltransferase, 4-(naphthalen-1-yl)-4-oxobutanoic acid, DIMETHYL SULFOXIDE, ...
Authors:Chen, Y., Kroeck, K., Sacco, M.
Deposit date:2019-09-20
Release date:2019-11-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.
Sci Rep, 9, 2019
6UED
  • Download 6ued
  • View 6ued
Molmil generated image of 6ued
APO PSEUDOMONAS AERUGINOSA LPXD STRUCTURE
Descriptor:UDP-3-O-acylglucosamine N-acyltransferase, GLYCEROL, MAGNESIUM ION
Authors:Chen, Y., Kroeck, K., Sacco, M.
Deposit date:2019-09-20
Release date:2019-11-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.
Sci Rep, 9, 2019
6UEE
  • Download 6uee
  • View 6uee
Molmil generated image of 6uee
PSEUDOMONAS AERUGINOSA LPXA COMPLEX STRUCTURE WITH LIGAND
Descriptor:Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, 4-(naphthalen-1-yl)-4-oxobutanoic acid, GLYCEROL
Authors:Chen, Y., Kroeck, K., Sacco, M.
Deposit date:2019-09-20
Release date:2019-11-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.
Sci Rep, 9, 2019
6UEG
  • Download 6ueg
  • View 6ueg
Molmil generated image of 6ueg
PSEUDOMONAS AERUGINOSA LPXA COMPLEX STRUCTURE WITH LIGAND
Descriptor:Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, 3-({2-[(2R)-2-carbamoyl-2,3-dihydro-4H-1,4-benzoxazin-4-yl]-2-oxoethyl}sulfanyl)propanoic acid, CALCIUM ION
Authors:Chen, Y., Kroeck, K., Sacco, M.
Deposit date:2019-09-20
Release date:2019-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography.
Sci Rep, 9, 2019
5V9U
  • Download 5v9u
  • View 5v9u
Molmil generated image of 5v9u
CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
Descriptor:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
Authors:Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
Deposit date:2017-03-23
Release date:2018-02-07
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
6JPJ
  • Download 6jpj
  • View 6jpj
Molmil generated image of 6jpj
CRYSTAL STRUCTURE OF FGF401 IN COMPLEX OF FGFR4
Descriptor:Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION
Authors:Zhou, Z., Chen, X., Chen, Y.
Deposit date:2019-03-27
Release date:2019-05-15
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.638 Å)
Cite:Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.
Chem.Commun.(Camb.), 55, 2019
5X07
  • Download 5x07
  • View 5x07
Molmil generated image of 5x07
CRYSTAL STRUCTURE OF FOXA2 DNA BINDING DOMAIN BOUND TO A FULL CONSENSUS DNA SITE
Descriptor:DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), Hepatocyte nuclear factor 3-beta
Authors:Li, J., Guo, M., Zhou, Z., Jiang, L., Chen, X., Qu, L., Wu, D., Chen, Z., Chen, L., Chen, Y.
Deposit date:2017-01-20
Release date:2017-08-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site
Biochemistry, 56, 2017
5XFF
  • Download 5xff
  • View 5xff
Molmil generated image of 5xff
CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550L)
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, Y.
Deposit date:2017-04-10
Release date:2018-09-05
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
5XFJ
  • Download 5xfj
  • View 5xfj
Molmil generated image of 5xfj
CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550M)
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, Y.
Deposit date:2017-04-10
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
2LJV
  • Download 2ljv
  • View 2ljv
Molmil generated image of 2ljv
SOLUTION STRUCTURE OF RHODOSTOMIN G50L MUTANT
Descriptor:Disintegrin rhodostomin
Authors:Chuang, W., Shiu, J., Chen, C., Chen, Y., Chang, Y., Huang, C.
Deposit date:2011-09-29
Release date:2012-10-03
Method:SOLUTION NMR
Cite:Design of Integrin AlphaVbeta3-Specific Disintegrin for Cancer Therapy
To be Published
2O14
  • Download 2o14
  • View 2o14
Molmil generated image of 2o14
X-RAY CRYSTAL STRUCTURE OF PROTEIN YXIM_BACSU FROM BACILLUS SUBTILIS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR595
Descriptor:Hypothetical protein yxiM, MANGANESE (II) ION, SULFATE ION
Authors:Kuzin, A.P., Chen, Y., Seetharaman, J., Chen, C.X., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-11-28
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray structure of the hypothetical protein YXIM_BACsu from Bacillus subtilis.
To be Published
2QGU
  • Download 2qgu
  • View 2qgu
Molmil generated image of 2qgu
THREE-DIMENSIONAL STRUCTURE OF THE PHOSPHOLIPID-BINDING PROTEIN FROM RALSTONIA SOLANACEARUM Q8XV73_RALSQ IN COMPLEX WITH A PHOSPHOLIPID AT THE RESOLUTION 1.53 A. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RSR89
Descriptor:Probable signal peptide protein, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE
Authors:Kuzin, A.P., Chen, Y., Jayaraman, S., Chen, C.X., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-06-29
Release date:2007-07-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structure of the phospholipid-binding protein from Ralstonia solanacearum Q8XV73_RALSQ in complex with a phospholipid at the resolution 1.53 A.
To be Published
3QRF
  • Download 3qrf
  • View 3qrf
Molmil generated image of 3qrf
STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER
Descriptor:Nuclear factor of activated T-cells, cytoplasmic 2, Forkhead box protein P3, ...
Authors:Bandukwala, H.S., Wu, Y., Feurer, M., Chen, Y., Barbosa, B., Ghosh, S., Stroud, J.C., Benoist, C., Mathis, D., Rao, A., Chen, L.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34, 2011
4EPK
  • Download 4epk
  • View 4epk
Molmil generated image of 4epk
EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, ZINC ION, MAGNESIUM ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-17
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.6009 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012