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4C0E
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STRUCTURE OF THE NOT1 SUPERFAMILY HOMOLOGY DOMAIN FROM CHAETOMIUM THERMOPHILUM
Descriptor:NOT1
Authors:Chen, Y., Boland, A., Raisch, T., Jonas, S., Izaurralde, E., Weichenrieder, O.
Deposit date:2013-08-01
Release date:2013-10-09
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and Assembly of the not Module of the Human Ccr4-not Complex
Nat.Struct.Mol.Biol., 20, 2013
4CRV
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COMPLEX OF HUMAN CNOT9 AND CNOT1 INCLUDING TWO TRYPTOPHANS
Descriptor:CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CELL DIFFERENTIATION PROTEIN RCD1 HOMOLOG, TRYPTOPHAN, ...
Authors:Boland, A., Chen, Y., Izaurralde, E., Weichenrieder, O.
Deposit date:2014-03-01
Release date:2014-05-07
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing
Mol.Cell, 54, 2014
4IIK
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LEGIONELLA PNEUMOPHILA EFFECTOR
Descriptor:Adenosine monophosphate-protein hydrolase SidD, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Tascon, I., Chen, Y., Neunuebel, M.R., Rojas, A.L., Machner, M.P., Hierro, A.
Deposit date:2012-12-20
Release date:2013-06-19
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD
Plos Pathog., 9, 2013
4IIP
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LEGIONELLA PNEUMOPHILA EFFECTOR
Descriptor:Adenosine monophosphate-protein hydrolase SidD, GLYCEROL, CHLORIDE ION
Authors:Tascon, I., Chen, Y., Neunuebel, M.R., Rojas, A.L., Machner, M.P., Hierro, A.
Deposit date:2012-12-20
Release date:2013-06-19
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD
Plos Pathog., 9, 2013
5SY1
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STRUCTURE OF THE STRA6 RECEPTOR FOR RETINOL UPTAKE IN COMPLEX WITH CALMODULIN
Descriptor:Calmodulin, STRA6, CALCIUM ION, ...
Authors:Clarke, O.B., Chen, Y., Mancia, F.
Deposit date:2016-08-10
Release date:2016-08-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the STRA6 receptor for retinol uptake.
Science, 353, 2016
5V9U
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
Descriptor:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
Authors:Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
Deposit date:2017-03-23
Release date:2018-02-07
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
6JPJ
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CRYSTAL STRUCTURE OF FGF401 IN COMPLEX OF FGFR4
Descriptor:Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION
Authors:Zhou, Z., Chen, X., Chen, Y.
Deposit date:2019-03-27
Release date:2019-05-15
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.638 Å)
Cite:Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.
Chem.Commun.(Camb.), 55, 2019
5X07
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CRYSTAL STRUCTURE OF FOXA2 DNA BINDING DOMAIN BOUND TO A FULL CONSENSUS DNA SITE
Descriptor:DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), Hepatocyte nuclear factor 3-beta
Authors:Li, J., Guo, M., Zhou, Z., Jiang, L., Chen, X., Qu, L., Wu, D., Chen, Z., Chen, L., Chen, Y.
Deposit date:2017-01-20
Release date:2017-08-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site
Biochemistry, 56, 2017
5XFF
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CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550L)
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, Y.
Deposit date:2017-04-10
Release date:2018-09-05
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
5XFJ
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CRYSTAL STRUCTURE OF LY2874455 IN COMPLEX OF FGFR4 GATEKEEPER MUTATION (V550M)
Descriptor:Fibroblast growth factor receptor 4, 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol
Authors:Wu, D., Chen, Y.
Deposit date:2017-04-10
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.
Chem. Commun. (Camb.), 54, 2018
2LJV
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SOLUTION STRUCTURE OF RHODOSTOMIN G50L MUTANT
Descriptor:Disintegrin rhodostomin
Authors:Chuang, W., Shiu, J., Chen, C., Chen, Y., Chang, Y., Huang, C.
Deposit date:2011-09-29
Release date:2012-10-03
Method:SOLUTION NMR
Cite:Design of Integrin AlphaVbeta3-Specific Disintegrin for Cancer Therapy
To be Published
2O14
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X-RAY CRYSTAL STRUCTURE OF PROTEIN YXIM_BACSU FROM BACILLUS SUBTILIS. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR595
Descriptor:Hypothetical protein yxiM, MANGANESE (II) ION, SULFATE ION
Authors:Kuzin, A.P., Chen, Y., Seetharaman, J., Chen, C.X., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-11-28
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray structure of the hypothetical protein YXIM_BACsu from Bacillus subtilis.
To be Published
2QGU
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THREE-DIMENSIONAL STRUCTURE OF THE PHOSPHOLIPID-BINDING PROTEIN FROM RALSTONIA SOLANACEARUM Q8XV73_RALSQ IN COMPLEX WITH A PHOSPHOLIPID AT THE RESOLUTION 1.53 A. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RSR89
Descriptor:Probable signal peptide protein, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE
Authors:Kuzin, A.P., Chen, Y., Jayaraman, S., Chen, C.X., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2007-06-29
Release date:2007-07-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structure of the phospholipid-binding protein from Ralstonia solanacearum Q8XV73_RALSQ in complex with a phospholipid at the resolution 1.53 A.
To be Published
3QRF
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STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER
Descriptor:Nuclear factor of activated T-cells, cytoplasmic 2, Forkhead box protein P3, ...
Authors:Bandukwala, H.S., Wu, Y., Feurer, M., Chen, Y., Barbosa, B., Ghosh, S., Stroud, J.C., Benoist, C., Mathis, D., Rao, A., Chen, L.
Deposit date:2011-02-17
Release date:2011-04-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34, 2011
4EPK
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EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, ZINC ION, MAGNESIUM ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-17
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.6009 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
4ERA
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EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, COBALT (II) ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-19
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
4ERG
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EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, FE (III) ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-20
Release date:2012-08-22
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
4ERI
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EVIDENCE FOR A DUAL ROLE OF AN ACTIVE SITE HISTIDINE IN ALPHA-AMINO-BETA-CARBOXYMUCONATE-EPSILON-SEMIALDEHYDE DECARBOXYLASE
Descriptor:2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, ZINC ION, MAGNESIUM ION
Authors:Huo, L., Fielding, A.J., Chen, Y., Li, T., Iwaki, H., Hosler, J.P., Chen, L., Hasegawa, Y., Que Jr., L., Liu, A.
Deposit date:2012-04-20
Release date:2012-08-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.0006 Å)
Cite:Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
4FKZ
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS UDP-GLCNAC 2-EPIMERASE IN COMPLEX WITH UDP-GLCNAC AND UDP
Descriptor:UDP-N-acetylglucosamine 2-epimerase, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, URIDINE-5'-DIPHOSPHATE
Authors:Yang, C.S., Chen, S.C., Kuan, S.M., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2012-06-14
Release date:2013-05-08
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal structure of Bacillus subtilis UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP
To be Published
4IWG
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CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN MJ0927 FROM METHANOCALDOCOCCUS JANNASCHII (IN C2221 FORM)
Descriptor:UPF0135 protein MJ0927
Authors:Kuan, S.M., Chen, S.C., Yang, C.S., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2013-01-23
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.472 Å)
Cite:Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii
To be Published
4IWM
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CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN MJ0927 FROM METHANOCALDOCOCCUS JANNASCHII (IN P21 FORM)
Descriptor:UPF0135 protein MJ0927
Authors:Kuan, S.M., Chen, S.C., Yang, C.S., Chen, Y.R., Liu, Y.H., Chen, Y.
Deposit date:2013-01-24
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii
To be Published
4IXA
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STRUCTURE OF DNA-BINDING DOMAIN OF THE RESPONSE REGULATOR SAER FROM STAPHYLOCOCCUS EPIDERMIDIS
Descriptor:Response regulator SaeR
Authors:Chen, Y.R., Chen, S.C., Yang, C.S., Kuan, S.M., Liu, Y.H., Chen, Y.
Deposit date:2013-01-24
Release date:2014-01-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus epidermidis
To be Published
4JIS
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CRYSTAL STRUCTURE OF RIBITOL 5-PHOSPHATE CYTIDYLYLTRANSFERASE (TARI) FROM BACILLUS SUBTILIS
Descriptor:ribitol-5-phosphate cytidylyltransferase
Authors:Yang, C.S., Chen, S.C., Chen, Y.R., Kuan, S.M., Liu, Y.H., Chen, Y.
Deposit date:2013-03-06
Release date:2014-03-12
Method:X-RAY DIFFRACTION (1.772 Å)
Cite:Crystal structure of ribitol 5-phosphate cytidylyltransferase (TarI) from Bacillus subtilis
To be Published
4KYH
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH ZOPOLRESTAT
Descriptor:Lactoylglutathione lyase, ZINC ION, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013
4KYK
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH INDOMETHACIN
Descriptor:Lactoylglutathione lyase, ZINC ION, INDOMETHACIN
Authors:Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
Deposit date:2013-05-29
Release date:2013-08-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Chemmedchem, 2013