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7AX1
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BU of 7ax1 by Molmil
Crystal structure of the human CCR4-CAF1 complex
Descriptor: CCR4-NOT transcription complex subunit 6, CCR4-NOT transcription complex subunit 7, MAGNESIUM ION
Authors:Chen, Y, Khazina, E, Weichenrieder, O.
Deposit date:2020-11-09
Release date:2021-05-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.
Nucleic Acids Res., 49, 2021
4V90
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BU of 4v90 by Molmil
Thermus thermophilus Ribosome
Descriptor: 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
Authors:Chen, Y, Feng, S, Kumar, V, Ero, R, Gao, Y.G.
Deposit date:2014-02-22
Release date:2014-07-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of EF-G-ribosome complex in a pretranslocation state.
Nat. Struct. Mol. Biol., 20, 2013
3D6A
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BU of 3d6a by Molmil
Crystal structure of the 2H-phosphatase domain of Sts-2 in complex with tungstate.
Descriptor: MAGNESIUM ION, SODIUM ION, Sts-2 protein, ...
Authors:Chen, Y, Carpino, N, Nassar, N.
Deposit date:2008-05-19
Release date:2009-03-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and functional characterization of the 2H-phosphatase domain of Sts-2 reveals an acid-dependent phosphatase activity.
Biochemistry, 48, 2009
6DWS
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BU of 6dws by Molmil
Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Descriptor: 8-{[(2-chlorophenyl)methyl]amino}adenosine, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION
Authors:Chen, Y, Antoshchenko, T, Smil, D, Zepeda, C, Huang, Y, Park, H.W.
Deposit date:2018-06-27
Release date:2019-07-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
To Be Published
7OKX
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BU of 7okx by Molmil
Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)-ELL2-EAF1 (composite structure)
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P.
Deposit date:2021-05-18
Release date:2021-07-14
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Allosteric transcription stimulation by RNA polymerase II super elongation complex.
Mol.Cell, 81, 2021
7OL0
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BU of 7ol0 by Molmil
Structure of active transcription elongation complex Pol II-DSIF (SPT5-KOW5)
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P.
Deposit date:2021-05-18
Release date:2021-07-14
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Allosteric transcription stimulation by RNA polymerase II super elongation complex.
Mol.Cell, 81, 2021
7OKY
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BU of 7oky by Molmil
Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure)
Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Chen, Y, Vos, S.M, Dienemann, C, Ninov, M, Urlaub, H, Cramer, P.
Deposit date:2021-05-18
Release date:2021-07-14
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Allosteric transcription stimulation by RNA polymerase II super elongation complex.
Mol.Cell, 81, 2021
2XEX
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BU of 2xex by Molmil
crystal structure of Staphylococcus aureus elongation factor G
Descriptor: CHLORIDE ION, ELONGATION FACTOR G, POTASSIUM ION
Authors:Chen, Y, Koripella, R.K, Sanyal, S, Selmer, M.
Deposit date:2010-05-19
Release date:2010-07-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Staphylococcus Aureus Elongation Factor G - Structure and Analysis of a Target for Fusidic Acid.
FEBS J., 277, 2010
6EBV
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BU of 6ebv by Molmil
Staphylococcus aureus Type II pantothenate kinase in complex with ADP and pantothenate analog Deoxy-N7-Pan
Descriptor: ADENOSINE-5'-DIPHOSPHATE, N-heptyl-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, Type II pantothenate kinase
Authors:Chen, Y, Antoshchenko, T, Strauss, E, Barnard, L, Huang, Y.H, Park, H.
Deposit date:2018-08-07
Release date:2019-08-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
4CRU
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BU of 4cru by Molmil
Complex of human CNOT9 and CNOT1 including one tryptophan
Descriptor: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CELL DIFFERENTIATION PROTEIN RCD1 HOMOLOG, GLYCEROL
Authors:Chen, Y, Boland, A, Izaurralde, E, Weichenrieder, O.
Deposit date:2014-03-01
Release date:2014-05-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing
Mol.Cell, 54, 2014
5UMB
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BU of 5umb by Molmil
Crystal structure of ATPase domain of Malaria GRP78 with ADP bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ...
Authors:Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H.
Deposit date:2017-01-26
Release date:2022-07-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Repurposing drugs to target the malaria parasite unfolding protein response.
Sci Rep, 8, 2018
4CRW
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BU of 4crw by Molmil
Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G)
Descriptor: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, GLYCEROL, PROBABLE ATP-DEPENDENT RNA HELICASE DDX6
Authors:Chen, Y, Boland, A, Izaurralde, E, Weichenrieder, O.
Deposit date:2014-03-01
Release date:2014-05-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing
Mol.Cell, 54, 2014
1J48
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BU of 1j48 by Molmil
Crystal Structure of Apo-C1027
Descriptor: Apoprotein of C1027
Authors:Chen, Y, Li, J, Liu, Y, Bartlam, M, Gao, Y, Jin, L, Tang, H, Shao, Y, Zhen, Y, Rao, Z.
Deposit date:2001-07-30
Release date:2003-06-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Apo-C1027 and Computer Modeling Analysis of C1027 Chromophore- Protein Complex
To be published
4WK8
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BU of 4wk8 by Molmil
FOXP3 forms a domain-swapped dimer to bridge DNA
Descriptor: DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), Forkhead box protein P3
Authors:Chen, Y, Chen, L.
Deposit date:2014-10-01
Release date:2015-01-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.4006 Å)
Cite:DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Nucleic Acids Res., 43, 2015
4HJE
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BU of 4hje by Molmil
Crystal structure of p53 core domain in complex with DNA
Descriptor: Cellular tumor antigen p53, DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), ...
Authors:Chen, Y, Chen, L.
Deposit date:2012-10-12
Release date:2013-07-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.907 Å)
Cite:Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.
Nucleic Acids Res., 41, 2013
7RPV
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BU of 7rpv by Molmil
Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1, ...
Authors:Chen, Y, Tolbert, D.W, Pazgier, M.
Deposit date:2021-08-04
Release date:2021-12-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.54 Å)
Cite:Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.
Biorxiv, 2021
1CZ8
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BU of 1cz8 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Descriptor: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ...
Authors:Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B.
Deposit date:1999-09-01
Release date:2000-03-20
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
8Z1E
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BU of 8z1e by Molmil
A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM
Descriptor: Uncharacterized protein UL78
Authors:Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W.
Deposit date:2024-04-11
Release date:2024-05-15
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM.
Cell Discov, 10, 2024
6R80
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BU of 6r80 by Molmil
Structure of AFF4 C-terminal homology domain
Descriptor: AF4/FMR2 family member 4
Authors:Chen, Y, Cramer, P.
Deposit date:2019-03-30
Release date:2019-06-12
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization.
J.Biol.Chem., 294, 2019
1K44
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BU of 1k44 by Molmil
Mycobacterium tuberculosis Nucleoside Diphosphate Kinase
Descriptor: Nucleoside Diphosphate Kinase
Authors:Chen, Y, Morera, S, Lascu, I, Janin, J.
Deposit date:2001-10-05
Release date:2002-05-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-ray structure of Mycobacterium tuberculosis nucleoside diphosphate kinase
Proteins, 47, 2002
1FLO
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BU of 1flo by Molmil
FLP Recombinase-Holliday Junction Complex I
Descriptor: FLP RECOMBINASE, PHOSPHONIC ACID, SYMMETRIZED FRT DNA SITES
Authors:Chen, Y, Narendra, U, Iype, L.E, Cox, M.M, Rice, P.A.
Deposit date:2000-08-14
Release date:2000-09-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of a Flp recombinase-Holliday junction complex: assembly of an active oligomer by helix swapping.
Mol.Cell, 6, 2000
4HC7
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BU of 4hc7 by Molmil
Crystal structure of the full DNA binding domain of GATA3-complex 2
Descriptor: DNA (5'-D(*AP*AP*GP*GP*TP*TP*AP*TP*CP*TP*CP*TP*GP*AP*TP*TP*TP*AP*GP*G)-3'), DNA (5'-D(*TP*TP*CP*CP*TP*AP*AP*AP*TP*CP*AP*GP*AP*GP*AP*TP*AP*AP*CP*C)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ...
Authors:Chen, Y, Bates, D.L, Dey, R, Chen, L.
Deposit date:2012-09-28
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation.
Cell Rep, 2, 2012
4HCA
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BU of 4hca by Molmil
DNA binding by GATA transcription factor-complex 1
Descriptor: DNA (5'-D(*AP*AP*TP*GP*TP*CP*CP*AP*TP*CP*TP*GP*AP*TP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*AP*TP*CP*AP*GP*AP*TP*GP*GP*AP*CP*A)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ...
Authors:Chen, Y, Bates, D.L, Dey, R, Chen, L.
Deposit date:2012-09-28
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation.
Cell Rep, 2, 2012
4HC9
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BU of 4hc9 by Molmil
DNA binding by GATA transcription factor-complex 3
Descriptor: DNA (5'-D(*AP*AP*GP*GP*TP*TP*AP*TP*CP*TP*CP*TP*GP*AP*TP*TP*TP*AP*GP*G)-3'), DNA (5'-D(*TP*TP*CP*CP*TP*AP*AP*AP*TP*CP*AP*GP*AP*GP*AP*TP*AP*AP*CP*C)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ...
Authors:Chen, Y, Bates, D.L, Dey, R, Chen, L.
Deposit date:2012-09-28
Release date:2012-12-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation.
Cell Rep, 2, 2012
1S5Z
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BU of 1s5z by Molmil
NDP kinase in complex with adenosine phosphonoacetic acid
Descriptor: ADENOSINE PHOSPHONOACETIC ACID, Nucleoside diphosphate kinase, cytosolic, ...
Authors:Chen, Y, Morera, S, Pasti, C, Angusti, A, Solaroli, N, Veron, M, Janin, J, Manfredini, S, Deville-Bonne, D.
Deposit date:2004-01-22
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Adenosine phosphonoacetic acid is slowly metabolized by NDP kinase.
Med.Chem., 1, 2005

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