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7ALP
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BU of 7alp by Molmil
Severe fever with thrombocytopenia syndrome virus (Phenuiviridae) L protein
Descriptor: MAGNESIUM ION, Replicase
Authors:Cusack, S, Rosenthal, M.
Deposit date:2020-10-07
Release date:2021-04-21
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Errors in the deposited SFTSV L protein structure.
Nat Microbiol, 6, 2021
1H3N
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BU of 1h3n by Molmil
Leucyl-tRNA synthetase from Thermus thermophilus complexed with a sulphamoyl analogue of leucyl-adenylate
Descriptor: LEUCINE, LEUCYL-TRNA SYNTHETASE, SULFATE ION, ...
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2002-09-11
Release date:2002-09-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue
Embo J., 19, 2000
9F2R
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BU of 9f2r by Molmil
Influenza A/H17N10 polymerase with bound promoter and 3' end of template in active site
Descriptor: 3' end of the promoter vRNA, 5' end of the promoter vRNA, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2024-04-23
Release date:2024-09-18
Method:X-RAY DIFFRACTION (1.959 Å)
Cite:High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit
To Be Published
9F37
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BU of 9f37 by Molmil
Replication-like initiation state of influenza polymerase with GTP and CTP at respectively the -1 and +1 positions (strain A/little yellow-shouldered bat/Guatemala/060/2010/H17N10)
Descriptor: 3' end of the vRNA promoter, 5' end of the vRNA promoter, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2024-04-25
Release date:2024-09-18
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit
Biorxiv, 2024
1SET
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BU of 1set by Molmil
CRYSTAL STRUCTURES AT 2.5 ANGSTROMS RESOLUTION OF SERYL-TRNA SYNTHETASE COMPLEXED WITH TWO DIFFERENT ANALOGUES OF SERYL-ADENYLATE
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, SERYL-tRNA SYNTHETASE
Authors:Cusack, S, Belrhali, H.
Deposit date:1994-02-21
Release date:1994-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate.
Science, 263, 1994
1SES
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BU of 1ses by Molmil
CRYSTAL STRUCTURES AT 2.5 ANGSTROMS RESOLUTION OF SERYL-TRNA SYNTHETASE COMPLEXED WITH TWO DIFFERENT ANALOGUES OF SERYL-ADENYLATE
Descriptor: ADENOSINE MONOPHOSPHATE, SERYL-HYDROXAMATE-ADENOSINE MONOPHOSPHATE, SERYL-tRNA SYNTHETASE
Authors:Cusack, S, Belrhali, H.
Deposit date:1994-02-21
Release date:1994-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate.
Science, 263, 1994
1OBH
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BU of 1obh by Molmil
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE
Descriptor: LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, NORVALINE, ...
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2003-01-31
Release date:2003-05-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1OBC
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BU of 1obc by Molmil
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor: 2'-AMINO-2'-DEOXYADENOSINE, LEUCINE, LEUCYL-TRNA SYNTHETASE, ...
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2003-01-30
Release date:2003-05-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
1H4V
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BU of 1h4v by Molmil
HISTIDYL-TRNA SYNTHETASE from Thermus Thermophilus (ligand free)
Descriptor: HISTIDYL-TRNA SYNTHETASE, SULFATE ION
Authors:Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:2001-05-14
Release date:2001-06-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Succession of Substrate Induced Conformational Changes Ensures the Amino Acid Specificity of Thermus Thermophilus Prolyl-tRNA Synthetase: Comparison with Histidyl-tRNA Synthetase
J.Mol.Biol., 309, 2001
6EUX
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BU of 6eux by Molmil
Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
Authors:Cusack, S, Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUY
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BU of 6euy by Molmil
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
Authors:Cusack, S, Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUW
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BU of 6euw by Molmil
Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
Authors:Cusack, S, Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
4WSB
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BU of 4wsb by Molmil
Bat Influenza A polymerase with bound vRNA promoter
Descriptor: Influenza A polymerase vRNA promoter 3' end, Influenza A polymerase vRNA promoter 5' end, PHOSPHATE ION, ...
Authors:Cusack, S, Pflug, A, Guilligay, D, Reich, S.
Deposit date:2014-10-26
Release date:2014-11-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insight into cap-snatching and RNA synthesis by influenza polymerase.
Nature, 516, 2014
7Z4O
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BU of 7z4o by Molmil
Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A
Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Cusack, S, Pflug, A.
Deposit date:2022-03-04
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.412 Å)
Cite:Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
7Z43
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BU of 7z43 by Molmil
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B
Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2022-03-03
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.123 Å)
Cite:Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
7Z42
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BU of 7z42 by Molmil
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B
Descriptor: DNA-directed RNA polymerase II subunit RPB1, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2022-03-03
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.418 Å)
Cite:Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
6EUV
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BU of 6euv by Molmil
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
Descriptor: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
Authors:Cusack, S, Lethier, M.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6Z6B
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BU of 6z6b by Molmil
Structure of full-length La Crosse virus L protein (polymerase)
Descriptor: RNA (5'-R(*GP*CP*UP*AP*CP*UP*AP*A)-3'), RNA (5'-R(P*AP*GP*UP*AP*GP*UP*GP*UP*GP*C)-3'), RNA (5'-R(P*UP*UP*AP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), ...
Authors:Cusack, S, Gerlach, P, Reguera, J.
Deposit date:2020-05-28
Release date:2020-07-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.961 Å)
Cite:Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
6F7J
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BU of 6f7j by Molmil
Crystal structure of Human ARS2 residues 171-270 + 408-763
Descriptor: Serrate RNA effector molecule homolog
Authors:Cusack, S, Schulze, W.M.
Deposit date:2017-12-10
Release date:2018-05-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Nat Commun, 9, 2018
6F7S
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BU of 6f7s by Molmil
Crystal structure of Human ARS2 residues 147-270 + 408-763 with deletion of loop B
Descriptor: Serrate RNA effector molecule homolog, Serrate RNA effector molecule homolog,Serrate RNA effector molecule homolog
Authors:Cusack, S, Schulze, W.M.
Deposit date:2017-12-11
Release date:2018-05-09
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Nat Commun, 9, 2018
1H3F
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BU of 1h3f by Molmil
Tyrosyl-tRNA synthetase from Thermus thermophilus complexed with tyrosinol
Descriptor: 4-[(2S)-2-amino-3-hydroxypropyl]phenol, SULFATE ION, TYROSYL-TRNA SYNTHETASE
Authors:Cusack, S, Yaremchuk, A, Kriklivyi, I, Tukalo, M.
Deposit date:2002-08-28
Release date:2002-09-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Class I Tyrosyl-tRNA Synthetase Has a Class II Mode or tRNA Recognition
Embo J., 21, 2002
7QTL
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BU of 7qtl by Molmil
Influenza A/H7N9 polymerase elongation complex
Descriptor: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-01-14
Release date:2022-12-28
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.48 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7R0E
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BU of 7r0e by Molmil
Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position
Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-02-01
Release date:2022-12-28
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.51 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7R1F
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BU of 7r1f by Molmil
Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106
Descriptor: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:Cusack, S, Kouba, T.
Deposit date:2022-02-02
Release date:2022-12-28
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.58 Å)
Cite:Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
1ADJ
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BU of 1adj by Molmil
HISTIDYL-TRNA SYNTHETASE IN COMPLEX WITH HISTIDINE
Descriptor: HISTIDINE, HISTIDYL-TRNA SYNTHETASE, SULFATE ION
Authors:Cusack, S, Aberg, A.
Deposit date:1997-02-18
Release date:1997-08-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase.
Biochemistry, 36, 1997

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