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7TUZ
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BU of 7tuz by Molmil
Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein
Descriptor: (2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol, G-protein coupled receptor 183, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Chen, H, Hung, W, Li, X.
Deposit date:2022-02-03
Release date:2022-04-13
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
Structure, 30, 2022
7TUY
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BU of 7tuy by Molmil
Cryo-EM structure of GSK682753A-bound EBI2/GPR183
Descriptor: 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, G-protein coupled receptor 183,Soluble cytochrome b562 fusion, anti-BRIL Fab Heavy chain, ...
Authors:Chen, H, Huang, W, Li, X.
Deposit date:2022-02-03
Release date:2022-04-13
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
Structure, 30, 2022
2PVF
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BU of 2pvf by Molmil
Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-09
Release date:2007-09-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZ5
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BU of 2pz5 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-17
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PSQ
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BU of 2psq by Molmil
Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain
Descriptor: Fibroblast growth factor receptor 2, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-07
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVY
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BU of 2pvy by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-10
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZR
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BU of 2pzr by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PY3
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BU of 2py3 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-15
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
7BRC
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BU of 7brc by Molmil
Crystal structure of the TMK3 LRR domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-like kinase TMK3
Authors:Chen, H, Kong, Y.Q, Chen, J, Li, L, Li, X.S, Yu, F, Ming, Z.H.
Deposit date:2020-03-27
Release date:2020-08-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structure of the extracellular domain of the receptor-like kinase TMK3 from Arabidopsis thaliana.
Acta Crystallogr.,Sect.F, 76, 2020
193D
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BU of 193d by Molmil
SOLUTION STRUCTURE OF A QUINOMYCIN BISINTERCALATOR-DNA COMPLEX
Descriptor: 3-HYDROXYQUINALDIC ACID, DNA (5'-D(*AP*CP*AP*CP*GP*TP*GP*T)-3'), QUINOMYCIN
Authors:Chen, H, Patel, D.J.
Deposit date:1994-09-30
Release date:1995-02-27
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:Solution Structure of a Quinomycin Bisintercalator-DNA Complex.
J.Mol.Biol., 246, 1995
2PZP
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BU of 2pzp by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2Q0B
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BU of 2q0b by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-21
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
6XE6
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BU of 6xe6 by Molmil
Structure of Human Dispatched-1 (DISP1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1
Authors:Chen, H, Liu, Y, Li, X.
Deposit date:2020-06-12
Release date:2020-07-08
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (4.54 Å)
Cite:Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis.
Life Sci Alliance, 3, 2020
8DJM
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BU of 8djm by Molmil
HMGCR-UBIAD1 Complex State 1
Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, CHOLESTEROL HEMISUCCINATE, Digitonin, ...
Authors:Chen, H, Qi, X, Li, X.
Deposit date:2022-07-01
Release date:2022-08-03
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.
Nat Commun, 13, 2022
8DJK
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BU of 8djk by Molmil
HMGCR-UBIAD1 Complex State 2
Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, CHOLESTEROL HEMISUCCINATE, Digitonin, ...
Authors:Chen, H, Qi, X, Li, X.
Deposit date:2022-06-30
Release date:2022-08-03
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.
Nat Commun, 13, 2022
202D
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BU of 202d by Molmil
SOLUTION STRUCTURE OF THE MENOGARIL-DNA COMPLEX
Descriptor: DNA (5'-D(*GP*AP*CP*AP*TP*GP*TP*C)-3'), MENOGARIL
Authors:Chen, H, Patel, D.J.
Deposit date:1995-03-29
Release date:1995-06-03
Last modified:2024-03-13
Method:SOLUTION NMR
Cite:Solution Structure of the Menogaril-DNA Complex
J.Am.Chem.Soc., 117, 1995
8G92
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BU of 8g92 by Molmil
Structure of inhibitor 16d-bound SPNS2
Descriptor: 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2
Authors:Chen, H, Li, X.
Deposit date:2023-02-21
Release date:2023-05-24
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Cell, 186, 2023
6W38
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BU of 6w38 by Molmil
Crystal structure of the FAM46C/Plk4 complex
Descriptor: Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C
Authors:Chen, H, Lu, D.F, Shang, G.J, Zhang, X.W.
Deposit date:2020-03-09
Release date:2020-05-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.48 Å)
Cite:Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 28, 2020
6W3I
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BU of 6w3i by Molmil
Crystal structure of a FAM46C mutant in complex with Plk4
Descriptor: Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C
Authors:Chen, H, Shang, G.J, Lu, D.F, Zhang, X.W.
Deposit date:2020-03-09
Release date:2020-05-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.802 Å)
Cite:Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 28, 2020
6W3J
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BU of 6w3j by Molmil
Crystal structure of the FAM46C/Plk4/Cep192 complex
Descriptor: Centrosomal protein of 192 kDa, Serine/threonine-protein kinase PLK4, Terminal nucleotidyltransferase 5C
Authors:Chen, H, Lu, D.F, Shang, G.J, Zhang, X.W.
Deposit date:2020-03-09
Release date:2020-05-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.385 Å)
Cite:Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 28, 2020
4IQ2
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BU of 4iq2 by Molmil
P21 crystal form of FKBP12.6
Descriptor: MALONIC ACID, Peptidyl-prolyl cis-trans isomerase FKBP1B
Authors:Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G.
Deposit date:2013-01-10
Release date:2014-01-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6.
Acta Crystallogr.,Sect.D, 70, 2014
4IQC
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BU of 4iqc by Molmil
P3121 crystal form of FKBP12.6
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B
Authors:Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G.
Deposit date:2013-01-11
Release date:2014-01-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6.
Acta Crystallogr.,Sect.D, 70, 2014
1FJB
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BU of 1fjb by Molmil
NMR Study of an 11-Mer DNA Duplex Containing 7,8-Dihydro-8-Oxoadenine (AOXO) Opposite Thymine
Descriptor: DNA (5'-D(*CP*GP*TP*AP*CP*(A38)P*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*TP*GP*TP*AP*CP*G)-3')
Authors:Chen, H, Johnson, F, Grollman, A.P, Patel, D.J.
Deposit date:1995-12-15
Release date:1996-06-10
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural Studies of the Ionizing Radiation Adduct 7,8-Dihydro-8-Oxoadenine (A Oxo) Positioned Opposite Thymine and Guanine in DNA Duplexes
MAGN.RESON.CHEM., 34, 1996
1FJA
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BU of 1fja by Molmil
NMR STUDY OF DEOXYRIBONUCLEIC ACID COMPLEXED WITH ACTINOMYCIN D
Descriptor: ACTINOMYCIN D, DNA (5'-D(*AP*AP*GP*CP*GP*CP*TP*T)-3')
Authors:Chen, H, Liu, X, Patel, D.J.
Deposit date:1995-12-15
Release date:1996-06-10
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:DNA Bending and Unwinding Associated with Actinomycin D Antibiotics Bound to Partially Overlapping Sites on DNA.
J.Mol.Biol., 258, 1996
4DM4
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BU of 4dm4 by Molmil
The conserved domain of yeast Cdc73
Descriptor: Cell division control protein 73
Authors:Chen, H, Shi, N, Gao, Y, Li, X, Niu, L, Teng, M.
Deposit date:2012-02-06
Release date:2012-08-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold.
Acta Crystallogr.,Sect.D, 68, 2012

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