PDB: 236 件ウェブページステータス検索Chemie searchBIRD

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2E6F	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate 分子名称: COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. 登録日 2006-12-26 公開日 2008-01-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with oxonate To be Published
2E68	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase, ... 著者 Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. 登録日 2006-12-26 公開日 2008-01-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate To be Published
2DJL	Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate 分子名称: COBALT HEXAMMINE(III), FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. 登録日 2006-04-04 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with succinate To be Published
2DJX	Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase 分子名称: COBALT HEXAMMINE(III), Dihydroorotate Dehydrogenase, FLAVIN MONONUCLEOTIDE 著者 Inaoka, D.K, Shimizu, H, Sakamoto, K, Shiba, T, Kurisu, G, Nara, T, Aoki, T, Harada, S, Kita, K. 登録日 2006-04-05 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase To be Published
2FPV	Dual binding mode of a novel series of DHODH inhibitors 分子名称: 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ... 著者 Baumgartner, R, Leban, J. 登録日 2006-01-17 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49, 2006
2FPT	Dual Binding Mode of a Novel Series of DHODH inhibitors 分子名称: 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ... 著者 Baumgartner, R, Walloschek, M, Kralik, M, Gotschlich, A, Tasler, S, Leban, J. 登録日 2006-01-17 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49, 2006
2FPY	Dual binding mode of a novel series of DHODH inhibitors 分子名称: 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ... 著者 Baumgartner, R, Leban, J. 登録日 2006-01-17 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49, 2006
2FQI	dual binding modes of a novel series of DHODH inhibitors 分子名称: 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID, ACETATE ION, Dihydroorotate dehydrogenase, ... 著者 Baumgartner, R, Leban, J. 登録日 2006-01-18 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49, 2006
2BX7	Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,5-dihydroxybenzoate 分子名称: 3,5-DIHYDROXYBENZOATE, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ... 著者 Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A. 登録日 2005-07-25 公開日 2006-08-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis. Biochemistry, 46, 2007
2BSL	Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,4-dihydroxybenzoate 分子名称: 3,4-DIHYDROXYBENZOIC ACID, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE A, ... 著者 Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A. 登録日 2005-05-23 公開日 2006-08-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis. Biochemistry, 46, 2007
2BXV	Dual binding mode of a novel series of DHODH inhibitors 分子名称: 2-({[3-FLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ... 著者 Baumgartner, R, Walloschek, M, Karlik, M, Gotschlich, A, Tasler, S, Mies, J, Leban, J. 登録日 2005-07-27 公開日 2006-08-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Dual binding mode of a novel series of DHODH inhibitors. J. Med. Chem., 49, 2006
2B4G	dihydroorotate dehydrogenase 分子名称: BROMIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) 登録日 2005-09-23 公開日 2005-10-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies Mol.Microbiol., 68, 2008
2B0M	Human dihydroorotate dehydrogenase bound to a novel inhibitor 分子名称: 3-AMIDO-5-BIPHENYL-BENZOIC ACID, Dihydroorotate dehydrogenase, mitochondrial, ... 著者 Hurt, D.E, Sutton, A.E, Clardy, J. 登録日 2005-09-14 公開日 2005-09-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg.Med.Chem.Lett., 16, 2006
1TV5	Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor 分子名称: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, Dihydroorotate dehydrogenase homolog, ... 著者 Hurt, D.E, Widom, J, Clardy, J. 登録日 2004-06-27 公開日 2005-09-06 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor. Acta Crystallogr.,Sect.D, 62, 2006
1UUM	Rat dihydroorotate dehydrogenase (DHOD)in complex with atovaquone 分子名称: 2-[4-(4-CHLOROPHENYL)CYCLOHEXYLIDENE]-3,4-DIHYDROXY-1(2H)-NAPHTHALENONE, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Hansen, M, Le Nours, J, Johansson, E, Antal, T, Ullrich, A, Loffler, M, Larsen, S. 登録日 2004-01-06 公開日 2004-04-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain Protein Sci., 13, 2004
1UUO	Rat dihydroorotate dehydrogenase (DHOD)in complex with brequinar 分子名称: 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... 著者 Hansen, M, Le Nours, J, Johansson, E, Antal, T, Ullrich, A, Loffler, M, Larsen, S. 登録日 2004-01-08 公開日 2004-04-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Inhibitor Binding in a Class 2 Dihydroorotate Dehydrogenase Causes Variations in the Membrane-Associated N-Terminal Domain Protein Sci., 13, 2004
1JQV	The K213E mutant of Lactococcus lactis Dihydroorotate dehydrogenase A 分子名称: ACETIC ACID, Dihydroorotate dehydrogenase A, FLAVIN MONONUCLEOTIDE, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-09 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JRB	The P56A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-13 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JUB	The K136E mutant of lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-24 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JQX	The R57A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-09 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JRC	The N67A mutant of Lactococcus lactis dihydroorotate dehydrogenase A 分子名称: FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-13 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1JUE	1.8 A resolution structure of native lactococcus lactis dihydroorotate dehydrogenase A 分子名称: ACETIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2001-08-24 公開日 2003-09-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
1OVD	THE K136E MUTANT OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE A IN COMPLEX WITH OROTATE 分子名称: DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... 著者 Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. 登録日 2003-03-26 公開日 2003-08-19 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function. J.Biol.Chem., 278, 2003
1F76	ESCHERICHIA COLI DIHYDROOROTATE DEHYDROGENASE 分子名称: Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, FORMIC ACID, ... 著者 Norager, S, Jensen, K.F, Bjornberg, O, Larsen, S. 登録日 2000-06-26 公開日 2002-10-16 最終更新日 2014-03-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinction between different classes of dihydroorotate dehydrogenases Structure, 10, 2002
1GT8	DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND URACIL-4-ACETIC ACID 分子名称: DIHYDROPYRIMIDINE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Dobritzsch, D, Ricagno, S, Schneider, G, Schnackerz, K.D, Lindqvist, Y. 登録日 2002-01-14 公開日 2002-04-11 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. J. Biol. Chem., 277, 2002

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