2FPY

Dual binding mode of a novel series of DHODH inhibitors

Summary for 2FPY

Entry DOI	10.2210/pdb2fpy/pdb
Related	2BXV 2FPT 2FPV 2FQI
Descriptor	Dihydroorotate dehydrogenase, mitochondrial precursor, ACETATE ION, SULFATE ION, ... (7 entities in total)
Functional Keywords	protein inhibitor complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains	1
Total formula weight	44817.22
Authors	Baumgartner, R.,Leban, J. (deposition date: 2006-01-17, release date: 2007-01-23, Last modification date: 2023-08-30)
Primary citation	Baumgartner, R.,Walloschek, M.,Kralik, M.,Gotschlich, A.,Tasler, S.,Mies, J.,Leban, J. Dual binding mode of a novel series of DHODH inhibitors. J.Med.Chem., 49:1239-1247, 2006 Cited by PubMed: 16480261 DOI: 10.1021/jm0506975 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation