2B0M

Human dihydroorotate dehydrogenase bound to a novel inhibitor

Summary for 2B0M

Entry DOI	10.2210/pdb2b0m/pdb
Related	1D3G 1D3H 1F76 1TV5 1UUM 1UUO
Descriptor	Dihydroorotate dehydrogenase, mitochondrial, 3-AMIDO-5-BIPHENYL-BENZOIC ACID, FLAVIN MONONUCLEOTIDE, ... (5 entities in total)
Functional Keywords	tim barrel; alpha/beta barrel, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion inner membrane; Single-pass membrane protein: Q02127
Total number of polymer chains	1
Total formula weight	43939.66
Authors	Hurt, D.E.,Sutton, A.E.,Clardy, J. (deposition date: 2005-09-14, release date: 2005-09-27, Last modification date: 2023-08-23)
Primary citation	Hurt, D.E.,Sutton, A.E.,Clardy, J. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg.Med.Chem.Lett., 16:1610-1615, 2006 Cited by PubMed: 16406782 DOI: 10.1016/j.bmcl.2005.12.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation