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1GT8

DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM PIG, TERNARY COMPLEX WITH NADPH AND URACIL-4-ACETIC ACID

Summary for 1GT8
Entry DOI10.2210/pdb1gt8/pdb
Related1GTE 1GTH 1H7W 1H7X
DescriptorDIHYDROPYRIMIDINE DEHYDROGENASE, IRON/SULFUR CLUSTER, FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
Functional Keywordselectron transfer, flavin, iron-sulfur clusters, pyrimidine catabolism, 5-fluorouracil degradation, oxidoreductase
Biological sourceSUS SCROFA (PIG)
Total number of polymer chains4
Total formula weight460669.37
Authors
Dobritzsch, D.,Ricagno, S.,Schneider, G.,Schnackerz, K.D.,Lindqvist, Y. (deposition date: 2002-01-14, release date: 2002-04-11, Last modification date: 2019-01-23)
Primary citationDobritzsch, D.,Ricagno, S.,Schneider, G.,Schnackerz, K.D.,Lindqvist, Y.
Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.
J. Biol. Chem., 277:13155-13166, 2002
Cited by
PubMed: 11796730
DOI: 10.1074/jbc.M111877200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

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