4RBW
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 5, HD5 (THR7ARG GLU21ARG MUTANT)
Descriptor:Defensin-5
Authors:Pazgier, M., Gohain, N., Tolbert, W.D.
Deposit date:2014-09-13
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
4RBX
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 5, HD5 (GLU21ARG MUTANT)
Descriptor:Defensin-5
Authors:Pazgier, M., Gohain, N., Tolbert, W.D.
Deposit date:2014-09-13
Release date:2015-07-29
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Design of a potent antibiotic peptide based on the active region of human defensin 5.
J.Med.Chem., 58, 2015
2MIT
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SOLUTION STRUCTURE OF OXIDIZED DIMERIC FORM OF HUMAN DEFENSIN 5
Descriptor:Defensin-5
Authors:Wommack, A.J., Ziarek, J.J., Wagner, G., Nolan, E.M.
Deposit date:2013-12-19
Release date:2014-09-17
Method:SOLUTION NMR
Cite:Solution structure of oxidized dimeric form of human defensin 5
To be Published
4LB1
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (HNP1) Y16A/F28A MUTANT
Descriptor:Neutrophil defensin 1
Authors:Tolbert, W.D., Wu, X., Pazgier, M.
Deposit date:2013-06-20
Release date:2013-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LB7
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (HNP1) Y16A/I20A/L25A/F28A MUTANT.
Descriptor:Neutrophil defensin 1
Authors:Tolbert, W.D., Wu, X., Pazgier, M.
Deposit date:2013-06-20
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LBB
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A MUTANT
Descriptor:Neutrophil defensin 1
Authors:Tolbert, W.D., Wu, X., Pazgier, M.
Deposit date:2013-06-20
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.719 Å)
Cite:Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
4LBF
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A MUTANT
Descriptor:Neutrophil defensin 1
Authors:Tolbert, W.D., Wu, X., Pazgier, M.
Deposit date:2013-06-20
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.
Plos One, 8, 2013
2LXZ
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SOLUTION STRUCTURE OF THE ANTIMICROBIAL PEPTIDE HUMAN DEFENSIN 5
Descriptor:Defensin-5
Authors:Wommack, A.J., Robson, S.A., Wanniarahchi, Y.A., Wan, A., Turner, C.J., Nolan, E.M.
Deposit date:2012-09-10
Release date:2012-11-28
Modification date:2013-02-20
Method:SOLUTION NMR
Cite:NMR solution structure and condition-dependent oligomerization of the antimicrobial Peptide human defensin 5.
Biochemistry, 51, 2012
4E82
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CRYSTAL STRUCTURE OF MONOMERIC VARIANT OF HUMAN ALPHA-DEFENSIN 5, HD5 (GLU21EME MUTANT)
Descriptor:Defensin-5
Authors:Pazgier, M.
Deposit date:2012-03-19
Release date:2012-05-16
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
J.Biol.Chem., 287, 2012
4E83
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 5, HD5 (LEU29NLE MUTANT)
Descriptor:Defensin-5
Authors:Pazgier, M.
Deposit date:2012-03-19
Release date:2012-05-16
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
J.Biol.Chem., 287, 2012
4E86
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 5, HD5 (LEU29ABA MUTANT)
Descriptor:Defensin-5
Authors:Wu, X., Pazgier, M.
Deposit date:2012-03-19
Release date:2012-05-16
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Functional determinants of human enteric {alpha}-defensin HD5: crucial role for hydrophobicity at dimer interface.
J.Biol.Chem., 287, 2012
4DU0
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1, HNP1 (G17A MUTANT)
Descriptor:Neutrophil defensin 1
Authors:Wu, X., Lu, W., Pazgier, M.
Deposit date:2012-02-21
Release date:2012-04-11
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1
J.Biol.Chem., 287, 2012
3QTE
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 6 (H27W MUTANT)
Descriptor:Defensin-6
Authors:Pazgier, M., Lu, W.
Deposit date:2011-02-22
Release date:2012-01-11
Modification date:2012-09-12
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Science, 337, 2012
3LVX
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (I6A MUTANT)
Descriptor:Crystal structure of human alpha-defensin 1 (I6A mutant)
Authors:Pazgier, M., Lu, W.
Deposit date:2010-02-22
Release date:2010-03-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO1
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (Y16A MUTANT)
Descriptor:Neutrophil defensin 1
Authors:Pazgier, M., Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO2
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (Y21A MUTANT)
Descriptor:Crystal structure of human alpha-defensin 1 (I6A mutant)
Authors:Pazgier, M., Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO4
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (R24A MUTANT)
Descriptor:Neutrophil defensin 1
Authors:Pazgier, M., Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Modification date:2011-08-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO6
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (W26ABA MUTANT)
Descriptor:Neutrophil defensin 1
Authors:Pazgier, M., Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LO9
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (W26AHP MUTANT)
Descriptor:Neutrophil defensin 1
Authors:Pazgier, M., Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3LOE
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (F28A MUTANT)
Descriptor:Neutrophil defensin 1
Authors:Pazgier, M., Lu, W.
Deposit date:2010-02-03
Release date:2010-03-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
3I5W
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 5 (MUTANT R13H)
Descriptor:Defensin-5
Authors:Pazgier, M., Lu, W.
Deposit date:2009-07-06
Release date:2009-07-28
Modification date:2012-04-11
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5
Febs Lett., 583, 2009
3HJD
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X-RAY STRUCTURE OF MONOMERIC VARIANT OF HNP1
Descriptor:Human neutrophil peptide 1
Authors:Lubkowski, J., Pazgier, M., Lu, W.
Deposit date:2009-05-21
Release date:2009-10-13
Modification date:2011-09-07
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:What Dictates the Multifaced Functions of the Human alpha-Defensin HNP?
To be Published
3HJ2
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CRYSTAL STRUCTURE OF COVALENT DIMER OF HNP1
Descriptor:Neutrophil defensin 1
Authors:Lubkowski, J., Pazgier, M., Lu, W.
Deposit date:2009-05-20
Release date:2009-10-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:What Dictates the Multifaced Functions of the Human alpha-Defensin HNP1?
To be Published
3H6C
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CRYSTAL STRUCTURE OF HUMAN ALPHA-DEFENSIN 1 (MUTANT GLN22ALA)
Descriptor:Neutrophil defensin 1
Authors:Pazgier, M., Lu, W.
Deposit date:2009-04-23
Release date:2010-03-09
Modification date:2011-08-17
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Trp-26 imparts functional versatility to human alpha-defensin HNP1.
J.Biol.Chem., 285, 2010
2KHT
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NMR STRUCTURE OF HUMAN ALPHA DEFENSIN HNP-1
Descriptor:Defensin, alpha 1
Authors:Zhang, Y., Li, S., Doherty, T.F., Lubkowski, J., Lu, W., Li, J., Barinka, C., Hong, M.
Deposit date:2009-04-11
Release date:2010-02-09
Modification date:2014-02-05
Method:SOLID-STATE NMR
Cite:Resonance assignment and three-dimensional structure determination of a human alpha-defensin, HNP-1, by solid-state NMR.
J.Mol.Biol., 397, 2010
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