3ZEH
 
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3F9K
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4FU6
 | | Crystal structure of the PSIP1 PWWP domain | | 分子名称: | GLYCEROL, PC4 and SFRS1-interacting protein, SULFATE ION, ... | | 著者 | Qin, S, Tempel, W, Xu, C, Wu, H, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2012-06-28 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure and function of the nucleosome-binding PWWP domain.
Trends Biochem.Sci., 39, 2014
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5YI9
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6EMO
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6EMR
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6EMQ
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6EMP
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5N88
 | | Crystal structure of antibody bound to viral protein | | 分子名称: | PC4 and SFRS1-interacting protein, VH59 antibody | | 著者 | Bao, L, Hannon, C, Cruz-Migoni, A, Ptchelkine, D, Sun, M.-y, Derveni, M, Bunjobpol, W, Chambers, J.S, Simmons, A, Phillips, S.E.V, Rabbitts, T.H. | | 登録日 | 2017-02-23 | | 公開日 | 2017-12-20 | | 最終更新日 | 2019-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.
Sci Rep, 7, 2017
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7PEL
 | | CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma | | 分子名称: | DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), Isoform 3 of PC4 and SFRS1-interacting protein,Isoform Gamma-2 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... | | 著者 | Barski, M, Pye, V.E, Nans, A, Cherepanov, P, Maertens, G.N. | | 登録日 | 2021-08-10 | | 公開日 | 2021-08-25 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.
Nat Commun, 11, 2020
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6ZV0
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6TVM
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5OYM
 | | HIV Integrase Binding Domain of Lens Epithelium-Derived Growth Factor | | 分子名称: | PC4 and SFRS1-interacting protein | | 著者 | Rabbitts, T.H, Phillips, S.E.V, Cruz-Migoni, A, Carr, S.B, Hannon, C. | | 登録日 | 2017-09-11 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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3U88
 | | Crystal structure of human menin in complex with MLL1 and LEDGF | | 分子名称: | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... | | 著者 | Huang, J, Wan, B, Lei, M. | | 登録日 | 2011-10-16 | | 公開日 | 2012-02-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
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7Z1Z
 | | MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution | | 分子名称: | DNA (37-MER), DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*TP*AP*GP*GP*GP*TP*G)-3'), ... | | 著者 | Pye, V.E, Ballandras-Colas, A, Cherepanov, P. | | 登録日 | 2022-02-25 | | 公開日 | 2022-05-11 | | 最終更新日 | 2022-12-21 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022
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2MTN
 | | Solution structure of MLL-IBD complex | | 分子名称: | Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein fusion | | 著者 | Cierpicki, T, Pollock, J, Murai, M. | | 登録日 | 2014-08-23 | | 公開日 | 2014-12-03 | | 最終更新日 | 2015-04-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.
Blood, 124, 2014
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7OUG
 | | STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir | | 分子名称: | DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), Integrase, ... | | 著者 | Barski, M.S, Ballandras-Colas, A, Cronin, N.B, Pye, V.E, Cherepanov, P, Maertens, G.N. | | 登録日 | 2021-06-11 | | 公開日 | 2021-08-18 | | 最終更新日 | 2021-10-06 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.
Nat Commun, 12, 2021
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8CBN
 | | structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | 著者 | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | | 登録日 | 2023-01-25 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
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6S01
 | | Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome | | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | 著者 | Wang, H, Farnung, L, Dienemann, C, Cramer, P. | | 登録日 | 2019-06-13 | | 公開日 | 2019-12-18 | | 最終更新日 | 2020-01-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding.
Nat.Struct.Mol.Biol., 27, 2020
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8CBQ
 | | structure of LEDGF/p75 PWWP domain bound to the H3K36 trimethylated dinucleosome | | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | 著者 | Koutna, E, Kouba, T, Novacek, J, Veverka, V. | | 登録日 | 2023-01-25 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
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3HPH
 | | Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD | | 分子名称: | GLYCEROL, Integrase, PC4 and SFRS1-interacting protein, ... | | 著者 | Hare, S, Wang, J, Cherepanov, P. | | 登録日 | 2009-06-04 | | 公開日 | 2009-07-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Structural basis for functional tetramerization of lentiviral integrase
Plos Pathog., 5, 2009
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3HPG
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2B4J
 | | Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 | | 分子名称: | GLYCEROL, Integrase (IN), PC4 and SFRS1 interacting protein, ... | | 著者 | Cherepanov, P, Ambrosio, A.L, Rahman, S, Ellenberger, T, Engelman, A. | | 登録日 | 2005-09-24 | | 公開日 | 2005-10-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Proc.Natl.Acad.Sci.Usa, 102, 2005
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6TRJ
 | | LEDGF/p75 IBD dimer | | 分子名称: | PC4 and SFRS1-interacting protein | | 著者 | Kugler, M, Brynda, J. | | 登録日 | 2019-12-19 | | 公開日 | 2020-09-09 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Fine-tuning of the LEDGF/p75 interaction network by dimerization
Structure
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2M16
 | | P75/LEDGF PWWP Domain | | 分子名称: | PC4 and SFRS1-interacting protein | | 著者 | Crowe, B.L, Foster, M.P. | | 登録日 | 2012-11-18 | | 公開日 | 2013-02-27 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.
Nucleic Acids Res., 41, 2013
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