3F9K

Two domain fragment of HIV-2 integrase in complex with LEDGF IBD

Summary for 3F9K

• Entry DOI: 10.2210/pdb3f9k/pdb
• Related: 1K6Y 2B4J
• Descriptor: Integrase, PC4 and SFRS1-interacting protein, ZINC ION, ... (4 entities in total)
• Functional Keywords: protein-protein complex, aids, dna integration, endonuclease, magnesium, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, host-virus interaction, transcription, transcription regulation, zinc binding, hhcc motif, viral protein, recombination
• Biological source: Human immunodeficiency virus type 2 (HIV-2); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584; Nucleus: O75475
• Total number of polymer chains: 36
• Total formula weight: 703193.57

Authors

Hare, S.,Cherepanov, P. (deposition date: 2008-11-14, release date: 2009-01-20, Last modification date: 2023-11-01)

• Primary citation: Hare, S.,Shun, M.C.,Gupta, S.S.,Valkov, E.,Engelman, A.,Cherepanov, P.; A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75; Plos Pathog., 5:e1000259-e1000259, 2009; PubMed: 19132083; DOI: 10.1371/journal.ppat.1000259

Experimental method

X-RAY DIFFRACTION (3.2 Å)