Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3F9K

Two domain fragment of HIV-2 integrase in complex with LEDGF IBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008270	molecular_function	zinc ion binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0008270	molecular_function	zinc ion binding
B	0015074	biological_process	DNA integration
E	0003676	molecular_function	nucleic acid binding
E	0008270	molecular_function	zinc ion binding
E	0015074	biological_process	DNA integration
F	0003676	molecular_function	nucleic acid binding
F	0008270	molecular_function	zinc ion binding
F	0015074	biological_process	DNA integration
I	0003676	molecular_function	nucleic acid binding
I	0008270	molecular_function	zinc ion binding
I	0015074	biological_process	DNA integration
J	0003676	molecular_function	nucleic acid binding
J	0008270	molecular_function	zinc ion binding
J	0015074	biological_process	DNA integration
M	0003676	molecular_function	nucleic acid binding
M	0008270	molecular_function	zinc ion binding
M	0015074	biological_process	DNA integration
N	0003676	molecular_function	nucleic acid binding
N	0008270	molecular_function	zinc ion binding
N	0015074	biological_process	DNA integration
Q	0003676	molecular_function	nucleic acid binding
Q	0008270	molecular_function	zinc ion binding
Q	0015074	biological_process	DNA integration
R	0003676	molecular_function	nucleic acid binding
R	0008270	molecular_function	zinc ion binding
R	0015074	biological_process	DNA integration
U	0003676	molecular_function	nucleic acid binding
U	0008270	molecular_function	zinc ion binding
U	0015074	biological_process	DNA integration
V	0003676	molecular_function	nucleic acid binding
V	0008270	molecular_function	zinc ion binding
V	0015074	biological_process	DNA integration
Y	0003676	molecular_function	nucleic acid binding
Y	0008270	molecular_function	zinc ion binding
Y	0015074	biological_process	DNA integration
Z	0003676	molecular_function	nucleic acid binding
Z	0008270	molecular_function	zinc ion binding
Z	0015074	biological_process	DNA integration
c	0003676	molecular_function	nucleic acid binding
c	0008270	molecular_function	zinc ion binding
c	0015074	biological_process	DNA integration
d	0003676	molecular_function	nucleic acid binding
d	0008270	molecular_function	zinc ion binding
d	0015074	biological_process	DNA integration
g	0003676	molecular_function	nucleic acid binding
g	0008270	molecular_function	zinc ion binding
g	0015074	biological_process	DNA integration
h	0003676	molecular_function	nucleic acid binding
h	0008270	molecular_function	zinc ion binding
h	0015074	biological_process	DNA integration
k	0003676	molecular_function	nucleic acid binding
k	0008270	molecular_function	zinc ion binding
k	0015074	biological_process	DNA integration
l	0003676	molecular_function	nucleic acid binding
l	0008270	molecular_function	zinc ion binding
l	0015074	biological_process	DNA integration
o	0003676	molecular_function	nucleic acid binding
o	0008270	molecular_function	zinc ion binding
o	0015074	biological_process	DNA integration
p	0003676	molecular_function	nucleic acid binding
p	0008270	molecular_function	zinc ion binding
p	0015074	biological_process	DNA integration
s	0003676	molecular_function	nucleic acid binding
s	0008270	molecular_function	zinc ion binding
s	0015074	biological_process	DNA integration
t	0003676	molecular_function	nucleic acid binding
t	0008270	molecular_function	zinc ion binding
t	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 210

Chain	Residue
A	HIS12
A	HIS16
A	CYS40
A	CYS43

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 211

Chain	Residue
A	ASP64
A	ASP116

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 210

Chain	Residue
B	CYS43
B	HIS12
B	HIS16
B	CYS40

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 211

Chain	Residue
B	ASP64
B	ASP116
e	GLU375

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 210

Chain	Residue
E	HIS12
E	HIS16
E	CYS40
E	CYS43

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 211

Chain	Residue
E	ASP64
E	ASP116

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 210

Chain	Residue
F	HIS12
F	HIS16
F	CYS40
F	CYS43

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG F 211

Chain	Residue
F	ASP64
F	ASP116

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 210

Chain	Residue
I	HIS12
I	HIS16
I	CYS40
I	CYS43

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG I 211

Chain	Residue
I	ASP64
I	ASP116

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 210

Chain	Residue
J	HIS12
J	HIS16
J	CYS40
J	CYS43

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG J 211

Chain	Residue
J	ASP64
J	ASP116
W	GLU375

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 210

Chain	Residue
M	HIS12
M	HIS16
M	CYS40
M	CYS43

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG M 211

Chain	Residue
M	ASP64
M	ASP116

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 210

Chain	Residue
N	HIS12
N	HIS16
N	CYS40
N	CYS43

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG N 211

Chain	Residue
G	GLU375
N	ASP64
N	CYS65
N	ASP116

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Q 210

Chain	Residue
Q	HIS12
Q	HIS16
Q	CYS40
Q	CYS43

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG Q 211

Chain	Residue
Q	ASP64
Q	ASP116

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN R 210

Chain	Residue
R	HIS12
R	HIS16
R	CYS40
R	CYS43

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG R 211

Chain	Residue
R	ASP64
R	ASP116

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN U 210

Chain	Residue
U	HIS12
U	HIS16
U	CYS40
U	CYS43

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG U 211

Chain	Residue
U	ASP64
U	ASP116

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN V 210

Chain	Residue
V	HIS12
V	HIS16
V	CYS40
V	CYS43

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG V 211

Chain	Residue
V	ASP64
V	ASP116

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Y 210

Chain	Residue
Y	HIS12
Y	HIS16
Y	CYS40
Y	CYS43

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG Y 211

Chain	Residue
Y	ASP64
Y	ASP116

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Z 210

Chain	Residue
Z	HIS12
Z	HIS16
Z	CYS40
Z	CYS43

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG Z 211

Chain	Residue
Z	ASP64
Z	ASP116

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN c 210

Chain	Residue
c	HIS12
c	HIS16
c	CYS40
c	CYS43

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG c 211

Chain	Residue
c	ASP64
c	ASP116

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN d 210

Chain	Residue
d	HIS12
d	HIS16
d	CYS40
d	CYS43

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG d 211

Chain	Residue
d	ASP116
d	ASP64

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN g 210

Chain	Residue
g	HIS12
g	HIS16
g	CYS40
g	CYS43

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG g 211

Chain	Residue
g	ASP64
g	ASP116

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN h 210

Chain	Residue
h	HIS12
h	HIS16
h	CYS40
h	CYS43

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG h 211

Chain	Residue
h	ASP64
h	ASP116

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN k 210

Chain	Residue
k	HIS12
k	HIS16
k	CYS40
k	CYS43

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG k 211

Chain	Residue
k	ASP64
k	ASP116

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN l 210

Chain	Residue
l	HIS12
l	HIS16
l	CYS40
l	CYS43

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG l 211

Chain	Residue
S	GLU375
l	ASP64
l	ASP116

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN o 210

Chain	Residue
o	HIS12
o	HIS16
o	CYS40
o	CYS43

site_id	EC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG o 211

Chain	Residue
o	ASP64
o	ASP116

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN p 210

Chain	Residue
p	HIS12
p	HIS16
p	CYS40
p	CYS43

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG p 211

Chain	Residue
p	ASP64
p	ASP116

site_id	EC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN s 210

Chain	Residue
s	HIS12
s	HIS16
s	CYS40
s	CYS43

site_id	FC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG s 211

Chain	Residue
s	ASP64
s	ASP116

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN t 210

Chain	Residue
t	HIS12
t	HIS16
t	CYS40
t	CYS43

site_id	FC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG t 211

Chain	Residue
t	ASP64
t	ASP116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	SER434
m	SER434
q	SER434
u	SER434
Y	GLU3-GLN44
Z	GLU3-GLN44
c	GLU3-GLN44
d	GLU3-GLN44
g	GLU3-GLN44
h	GLU3-GLN44
k	GLU3-GLN44
G	SER434
l	GLU3-GLN44
o	GLU3-GLN44
p	GLU3-GLN44
s	GLU3-GLN44
t	GLU3-GLN44
K	SER434
O	SER434
S	SER434
W	SER434
a	SER434
e	SER434
i	SER434

site_id	SWS_FT_FI2
Number of Residues	96
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00450

Chain	Residue	Details
A	HIS12
E	HIS16
E	CYS40
E	CYS43
F	HIS12
F	HIS16
F	CYS40
F	CYS43
I	HIS12
I	HIS16
I	CYS40
A	HIS16
I	CYS43
J	HIS12
J	HIS16
J	CYS40
J	CYS43
M	HIS12
M	HIS16
M	CYS40
M	CYS43
N	HIS12
A	CYS40
N	HIS16
N	CYS40
N	CYS43
Q	HIS12
Q	HIS16
Q	CYS40
Q	CYS43
R	HIS12
R	HIS16
R	CYS40
A	CYS43
R	CYS43
U	HIS12
U	HIS16
U	CYS40
U	CYS43
V	HIS12
V	HIS16
V	CYS40
V	CYS43
Y	HIS12
B	HIS12
Y	HIS16
Y	CYS40
Y	CYS43
Z	HIS12
Z	HIS16
Z	CYS40
Z	CYS43
c	HIS12
c	HIS16
c	CYS40
B	HIS16
c	CYS43
d	HIS12
d	HIS16
d	CYS40
d	CYS43
g	HIS12
g	HIS16
g	CYS40
g	CYS43
h	HIS12
B	CYS40
h	HIS16
h	CYS40
h	CYS43
k	HIS12
k	HIS16
k	CYS40
k	CYS43
l	HIS12
l	HIS16
l	CYS40
B	CYS43
l	CYS43
o	HIS12
o	HIS16
o	CYS40
o	CYS43
p	HIS12
p	HIS16
p	CYS40
p	CYS43
s	HIS12
E	HIS12
s	HIS16
s	CYS40
s	CYS43
t	HIS12
t	HIS16
t	CYS40
t	CYS43

site_id	SWS_FT_FI3
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP64
I	ASP116
J	ASP64
J	ASP116
M	ASP64
M	ASP116
N	ASP64
N	ASP116
Q	ASP64
Q	ASP116
R	ASP64
A	ASP116
R	ASP116
U	ASP64
U	ASP116
V	ASP64
V	ASP116
Y	ASP64
Y	ASP116
Z	ASP64
Z	ASP116
c	ASP64
B	ASP64
c	ASP116
d	ASP64
d	ASP116
g	ASP64
g	ASP116
h	ASP64
h	ASP116
k	ASP64
k	ASP116
l	ASP64
B	ASP116
l	ASP116
o	ASP64
o	ASP116
p	ASP64
p	ASP116
s	ASP64
s	ASP116
t	ASP64
t	ASP116
E	ASP64
E	ASP116
F	ASP64
F	ASP116
I	ASP64

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P04585

Chain	Residue	Details
A	GLU152
R	GLU152
U	GLU152
V	GLU152
Y	GLU152
Z	GLU152
c	GLU152
d	GLU152
g	GLU152
h	GLU152
k	GLU152
B	GLU152
l	GLU152
o	GLU152
p	GLU152
s	GLU152
t	GLU152
E	GLU152
F	GLU152
I	GLU152
J	GLU152
M	GLU152
N	GLU152
Q	GLU152

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)