3F9K

Two domain fragment of HIV-2 integrase in complex with LEDGF IBD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F, I...	Integrase	polymer	210	23672.0	24	UniProt (P04584) Pfam (PF02022) Pfam (PF00665) In PDB	Human immunodeficiency virus type 2 (HIV-2)
2	C, G, K, O, S...	PC4 and SFRS1-interacting protein	polymer	95	11076.0	12	UniProt (O75475) Pfam (PF11467) In PDB	Homo sapiens (Human)	LEDGF, Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, Dense fine speckles 70 kDa protein, DFS 70, CLL-associated antigen KW-7
3	Q, p, R, s, U...	ZINC ION	non-polymer		65.4	24	Chemie (ZN)
4	Q, p, R, s, U...	MAGNESIUM ION	non-polymer		24.3	24	Chemie (MG)

Sequence modifications

A, B, E, F, I, J, M, N, Q, R, U, V, Y, Z, c, d, g, h, k, l, o, p, s, t: 2 - 209 (UniProt: P04584)

PDB	External Database	Details
Met 0	-	expression tag
Val 1	-	expression tag
Val 180	Ile 1351	variant

C, G, K, O, S, W, a, e, i, m, q, u: 347 - 435 (UniProt: O75475)

PDB	External Database	Details
Leu 436	-	expression tag
Glu 437	-	expression tag
Val 438	-	expression tag
Leu 439	-	expression tag
Phe 440	-	expression tag
Gln 441	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	36
	Total formula weight	701040.4
Non-Polymers*	Number of molecules	48
	Total formula weight	2153.1
All*	Total formula weight	703193.6

*Water molecules are not included.