4FU6

Crystal structure of the PSIP1 PWWP domain

Summary for 4FU6

• Entry DOI: 10.2210/pdb4fu6/pdb
• Descriptor: PC4 and SFRS1-interacting protein, SULFATE ION, GLYCEROL, ... (5 entities in total)
• Functional Keywords: structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : O75475
• Total number of polymer chains: 1
• Total formula weight: 17898.66

Authors

Qin, S.,Tempel, W.,Xu, C.,Wu, H.,Dong, A.,Cerovina, T.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2012-06-28, release date: 2012-08-29, Last modification date: 2023-09-13)

Primary citation

Qin, S.,Min, J.
Structure and function of the nucleosome-binding PWWP domain.
Trends Biochem.Sci., 39:536-547, 2014

PubMed Abstract: PWWP domain-containing proteins are often involved in chromatin-associated biological processes, such as transcriptional regulation and DNA repair, and recent studies have shown that the PWWP domain specifies chromatin localization. Mutations in the PWWP domain, a 100-150 amino acid motif, have been linked to various human diseases, emphasizing its importance. Structural studies reveal that PWWP domains possess a conserved aromatic cage for histone methyl-lysine recognition, and synergistically bind both histone and DNA, which contributes to their nucleosome-binding ability and chromatin localization. Furthermore, the PWWP domain often cooperates with other histone and DNA 'reader' or 'modifier' domains to evoke crosstalk between various epigenetic marks. Here, we discuss these recent advances in understanding the structure and function of the PWWP domain.

PubMed: 25277115
DOI: 10.1016/j.tibs.2014.09.001

Experimental method

X-RAY DIFFRACTION (2.1 Å)