2B4J

Structural basis for the recognition between HIV-1 integrase and LEDGF/p75

Summary for 2B4J

Related1z9e 1ITG 1K6Y
DescriptorIntegrase (IN), PC4 and SFRS1 interacting protein, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordshiv, integration, transcription, viral protein, recombination
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P12497
Nucleus  O75475
Total number of polymer chains4
Total molecular weight59524.24
Authors
Cherepanov, P.,Ambrosio, A.L.,Rahman, S.,Ellenberger, T.,Engelman, A. (deposition date: 2005-09-24, release date: 2005-10-25, Last modification date: 2017-10-11)
Primary citation
Cherepanov, P.,Ambrosio, A.L.,Rahman, S.,Ellenberger, T.,Engelman, A.
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Proc.Natl.Acad.Sci.Usa, 102:17308-17313, 2005
PubMed: 16260736 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0506924102
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.02 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22470 3.9% 4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171313
PDB entries from 2020-11-18