2B4J
Structural basis for the recognition between HIV-1 integrase and LEDGF/p75
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase (IN) | polymer | 166 | 18194.8 | 2 | UniProt (P12497) Pfam (PF00665) | Human immunodeficiency virus 1 | |
| 2 | C, D (C, D) | PC4 and SFRS1 interacting protein | polymer | 98 | 11288.2 | 2 | UniProt (O75475) Pfam (PF11467) | Homo sapiens (human) | Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, Dense fine speckles 70 kDa protein, DFS 70, CLL-associated antigen KW-7 |
| 3 | E, G (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | F, H, I, J (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 50 - 212 (UniProt: P12497)
C, D: 347 - 442 (UniProt: O75475)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | cloning artifact |
| Ser 48 | - | cloning artifact |
| His 49 | - | cloning artifact |
| Lys 185 | Phe 900 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 345 | - | cloning artifact |
| Ser 346 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58965.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 558.3 | |
| All* | Total formula weight | 59524.2 |
