5N88

Crystal structure of antibody bound to viral protein

Summary for 5N88

• Entry DOI: 10.2210/pdb5n88/pdb
• Descriptor: VH59 antibody, PC4 and SFRS1-interacting protein, ... (4 entities in total)
• Functional Keywords: mll: hiv: intracellular antibody: integrase: ledgf, aids, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 46424.86

Authors

Bao, L.,Hannon, C.,Cruz-Migoni, A.,Ptchelkine, D.,Sun, M.-y.,Derveni, M.,Bunjobpol, W.,Chambers, J.S.,Simmons, A.,Phillips, S.E.V.,Rabbitts, T.H. (deposition date: 2017-02-23, release date: 2017-12-20, Last modification date: 2019-10-16)

• Primary citation: Bao, L.,Hannon, C.,Cruz-Mignoni, A.,Ptchelkine, D.,Sun, M.Y.,Miller, A.,Bunjobpol, W.,Quevedo, C.E.,Derveni, M.,Chambers, J.,Simmons, A.,Phillips, S.E.V.,Rabbitts, T.H.; Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.; Sci Rep, 7:16869-16869, 2017; PubMed: 29203900; DOI: 10.1038/s41598-017-16742-2

Experimental method

X-RAY DIFFRACTION (1.7 Å)