8P4C
| Structural insights into human co-transcriptional capping - structure 3 | 分子名称: | DNA (32-MER), DNA (41-MER), DNA-directed RNA polymerase II subunit E, ... | 著者 | Garg, G, Dienemann, C, Farnung, L, Schwarz, J, Linden, A, Urlaub, H, Cramer, P. | 登録日 | 2023-05-20 | 公開日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into human co-transcriptional capping. Mol.Cell, 83, 2023
|
|
4MZG
| Crystal structure of human Spindlin1 bound to histone H3K4me3 peptide | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... | 著者 | Su, X, Ding, X, Li, H. | 登録日 | 2013-09-30 | 公開日 | 2014-03-26 | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | 主引用文献 | Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1 Genes Dev., 28, 2014
|
|
6P7G
| The co-crystal structure of BRAF(V600E) with PHI1 | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide, Serine/threonine-protein kinase B-raf | 著者 | Agianian, B, Gavathiotis, E. | 登録日 | 2019-06-05 | 公開日 | 2020-09-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Inhibitors of BRAF dimers using an allosteric site. Nat Commun, 11, 2020
|
|
6PI7
| |
6P3D
| The co-crystal structure of BRAF(V600E) with ponatinib | 分子名称: | 1,2-ETHANEDIOL, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, AMMONIUM ION, ... | 著者 | Agianian, B, Gavathiotis, E. | 登録日 | 2019-05-23 | 公開日 | 2020-09-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Inhibitors of BRAF dimers using an allosteric site. Nat Commun, 11, 2020
|
|
4NUF
| Crystal Structure of SHP/EID1 | 分子名称: | EID1 peptide, Maltose ABC transporter periplasmic protein, Nuclear receptor subfamily 0 group B member 2 chimeric construct, ... | 著者 | Zhi, X, Zhou, X.E, He, Y, Zechner, C, Suino-Powell, K.M, Kliewer, S.A, Melcher, K, Mangelsdorf, D.J, Xu, H.E. | 登録日 | 2013-12-03 | 公開日 | 2014-01-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into gene repression by the orphan nuclear receptor SHP. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
6Q0J
| Structure of a MAPK pathway complex | 分子名称: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Park, E, Rawson, S, Jeon, H, Eck, M.J. | 登録日 | 2019-08-01 | 公開日 | 2019-10-09 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
|
|
6PZV
| |
6Q0K
| Structure of a MAPK pathway complex | 分子名称: | 14-3-3 protein zeta/delta, Serine/threonine-protein kinase B-raf | 著者 | Park, E, Rawson, S, Jeon, H, Eck, M.J. | 登録日 | 2019-08-01 | 公開日 | 2019-10-09 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
|
|
8QQG
| Structure of BRAF in Complex With Exarafenib (KIN-2787). | 分子名称: | (3~{S})-~{N}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{R})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamide, CHLORIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Schmitt, A, Costanzi, E, Kania, R, Chen, Y.K. | 登録日 | 2023-10-04 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.979 Å) | 主引用文献 | Structure of BRAF in Complex With Exarafenib (KIN-2787). To Be Published
|
|
4O62
| CW-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3 | 分子名称: | Histone H3.3, UNKNOWN ATOM OR ION, ZINC ION, ... | 著者 | Liu, Y, Tempel, W, Dong, A, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2013-12-20 | 公開日 | 2014-03-26 | 最終更新日 | 2016-06-08 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins. J.Biol.Chem., 291, 2016
|
|
6Q0T
| Structure of a MAPK pathway complex | 分子名称: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Park, E, Rawson, S, Jeon, H, Eck, M.J. | 登録日 | 2019-08-02 | 公開日 | 2019-10-09 | 最終更新日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature, 575, 2019
|
|
8SIY
| |
6PWV
| Cryo-EM structure of MLL1 core complex bound to the nucleosome | 分子名称: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | 登録日 | 2019-07-23 | 公開日 | 2019-12-18 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nat Commun, 10, 2019
|
|
4OUC
| Structure of human haspin in complex with histone H3 substrate | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 1,2-ETHANEDIOL, Histone H3.2, ... | 著者 | Chaikuad, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2014-02-15 | 公開日 | 2014-04-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Modulation of the chromatin phosphoproteome by the haspin protein kinase. Mol Cell Proteomics, 13, 2014
|
|
8SWI
| |
8SR6
| |
6R1U
| Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 2 | 分子名称: | DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, Histone H2A, ... | 著者 | Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. | 登録日 | 2019-03-15 | 公開日 | 2019-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.36 Å) | 主引用文献 | A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
|
|
6R25
| Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 3 | 分子名称: | DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, H2B, ... | 著者 | Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. | 登録日 | 2019-03-15 | 公開日 | 2019-04-24 | 実験手法 | ELECTRON MICROSCOPY (4.61 Å) | 主引用文献 | A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
|
|
8THU
| |
8T9H
| |
8T9F
| |
4PP7
| Highly Potent and Selective 3-N-methylquinazoline-4(3H)-one Based Inhibitors of B-RafV600E Kinase | 分子名称: | N-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide, Serine/threonine-protein kinase B-raf | 著者 | Wenglowsky, S, Ren, L, Grina, J, Hansen, J.D, Laird, E.R, Moreno, D, Dinkel, V, Gloor, S.L, Hastings, G, Rana, S, Rasor, K, Sturgis, H.L, Voegtli, W.C, Vigers, G.P.A, Willis, B, Mathieu, S, Rudolph, J. | 登録日 | 2014-02-26 | 公開日 | 2014-04-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 24, 2014
|
|
6QXZ
| Solution structure of the ASHH2 CW domain with the N-terminal histone H3 tail mimicking peptide monomethylated on lysine 4 | 分子名称: | ALA-ARG-THR-MLZ-GLN-THR-ALA-ARG-TYR, Histone-lysine N-methyltransferase ASHH2, ZINC ION | 著者 | Dobrovolska, O, Madeleine, N, Teigen, K, Halskau, O, Bril'kov, M. | 登録日 | 2019-03-08 | 公開日 | 2019-12-04 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection. Febs J., 287, 2020
|
|
8T4R
| |