6PZV

Crystal Structure of Bovine DNMT1 RFTS domain in complex with H3K9me3 and Ubiquitin

Summary for 6PZV

• Entry DOI: 10.2210/pdb6pzv/pdb
• Descriptor: Ubiquitin, DNA (cytosine-5)-methyltransferase 1, Histone H3.3, ... (6 entities in total)
• Functional Keywords: dna methylation, dna methyltransferase 1, histone modification, ubiquitylation, dna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 96785.46

Authors

Ren, W.,Song, J. (deposition date: 2019-08-01, release date: 2020-07-15, Last modification date: 2020-08-12)

• Primary citation: Ren, W.,Fan, H.,Grimm, S.A.,Guo, Y.,Kim, J.J.,Yin, J.,Li, L.,Petell, C.J.,Tan, X.F.,Zhang, Z.M.,Coan, J.P.,Gao, L.,Cai, L.,Detrick, B.,Cetin, B.,Cui, Q.,Strahl, B.D.,Gozani, O.,Wang, Y.,Miller, K.M.,O'Leary, S.E.,Wade, P.A.,Patel, D.J.,Wang, G.G.,Song, J.; Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.; Proc.Natl.Acad.Sci.USA, 117:18439-18447, 2020; PubMed: 32675241; DOI: 10.1073/pnas.2009316117

Experimental method

X-RAY DIFFRACTION (3.01 Å)