6PZV
Crystal Structure of Bovine DNMT1 RFTS domain in complex with H3K9me3 and Ubiquitin
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue FLC C 601 |
| Chain | Residue |
| C | THR352 |
| G | LEU432 |
| G | ASN455 |
| C | LEU358 |
| C | ARG414 |
| C | HOH701 |
| G | GLU366 |
| G | HIS368 |
| G | TYR411 |
| G | LYS413 |
| G | GLY415 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 602 |
| Chain | Residue |
| C | CYS351 |
| C | CYS354 |
| C | CYS412 |
| C | HIS416 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 601 |
| Chain | Residue |
| G | CYS351 |
| G | CYS354 |
| G | CYS412 |
| G | HIS416 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| A | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| D | ARG2 | |
| H | ARG2 | |
| C | CYS412 | |
| C | HIS416 | |
| G | CYS351 | |
| G | CYS354 | |
| G | CYS412 | |
| G | HIS416 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692 |
| Chain | Residue | Details |
| D | THR3 | |
| H | THR3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| D | LYS4 | |
| H | LYS4 | |
| C | SER547 | |
| G | SER392 | |
| G | SER396 | |
| G | SER547 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| D | GLN5 | |
| H | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| D | THR6 | |
| H | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P84244 |
| Chain | Residue | Details |
| D | ARG8 | |
| H | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708, ECO:0000269|PubMed:7309716 |
| Chain | Residue | Details |
| D | M3L9 | |
| H | M3L9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15851689, ECO:0000269|PubMed:16185088 |
| Chain | Residue | Details |
| D | SER10 | |
| H | SER10 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| D | THR11 | |
| H | THR11 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| D | LYS14 | |
| H | LYS14 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| D | ARG17 | |
| H | ARG17 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| D | CYS18 | |
| H | CYS18 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| D | CYS23 | |
| H | CYS23 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| D | TRP26 | |
| H | TRP26 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| D | CYS18 | |
| H | CYS18 |
