6P3D

The co-crystal structure of BRAF(V600E) with ponatinib

Summary for 6P3D

• Entry DOI: 10.2210/pdb6p3d/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, SULFATE ION, ... (6 entities in total)
• Functional Keywords: kinase, inhibitor, cancer, melanoma, transferase-transferase inhibitor complex, oncoprotein, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35195.90

Authors

Agianian, B.,Gavathiotis, E. (deposition date: 2019-05-23, release date: 2020-09-23, Last modification date: 2024-03-13)

• Primary citation: Cotto-Rios, X.M.,Agianian, B.,Gitego, N.,Zacharioudakis, E.,Giricz, O.,Wu, Y.,Zou, Y.,Verma, A.,Poulikakos, P.I.,Gavathiotis, E.; Inhibitors of BRAF dimers using an allosteric site.; Nat Commun, 11:4370-4370, 2020; PubMed: 32873792; DOI: 10.1038/s41467-020-18123-2

Experimental method

X-RAY DIFFRACTION (2.11 Å)