6P7G

The co-crystal structure of BRAF(V600E) with PHI1

Summary for 6P7G

Entry DOI	10.2210/pdb6p7g/pdb
Descriptor	Serine/threonine-protein kinase B-raf, 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (4 entities in total)
Functional Keywords	kinase, inhibitor, cancer, melanoma, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	137468.30
Authors	Agianian, B.,Gavathiotis, E. (deposition date: 2019-06-05, release date: 2020-09-23, Last modification date: 2024-03-13)
Primary citation	Cotto-Rios, X.M.,Agianian, B.,Gitego, N.,Zacharioudakis, E.,Giricz, O.,Wu, Y.,Zou, Y.,Verma, A.,Poulikakos, P.I.,Gavathiotis, E. Inhibitors of BRAF dimers using an allosteric site. Nat Commun, 11:4370-4370, 2020 Cited by PubMed: 32873792 DOI: 10.1038/s41467-020-18123-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation