5P9M
| BTK1 BINDS COVALENTLY TO HY-15771 ONO-4059 | 分子名称: | 6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK | 著者 | Gardberg, A.S. | 登録日 | 2016-09-20 | 公開日 | 2017-05-24 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91, 2017
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5P9I
| BTK1 SOAKED WITH IBRUTINIB-Rev | 分子名称: | 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, DIMETHYL SULFOXIDE, Tyrosine-protein kinase BTK | 著者 | Gardberg, A.S. | 登録日 | 2016-09-20 | 公開日 | 2017-05-24 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | 主引用文献 | Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91, 2017
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5P9K
| CRYSTAL STRUCTURE OF BTK with CNX 774 | 分子名称: | 4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{N}-methyl-pyridine-2-carboxamide, Tyrosine-protein kinase BTK | 著者 | Gardberg, A.S. | 登録日 | 2016-09-20 | 公開日 | 2017-05-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91, 2017
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5QIN
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8FV3
| EGFR(T790M/V948R) in complex with compound 1 (LN4503) | 分子名称: | Epidermal growth factor receptor, MAGNESIUM ION, N-{(4P)-4-[(4P)-5-{3-[(8-fluoro-11-oxo-5,11-dihydro-10H-dibenzo[b,e][1,4]diazepin-10-yl)methyl]phenyl}-2-(methylsulfanyl)-1H-imidazol-4-yl]pyridin-2-yl}acetamide, ... | 著者 | Ogboo, B.C, Heppner, D.E. | 登録日 | 2023-01-18 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem, 7, 2024
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8FV4
| EGFR(T790M/V948R) in complex with compound 2 (LN5993) | 分子名称: | Epidermal growth factor receptor, MAGNESIUM ION, N-{(3P)-3-[(4P)-4-(2-acetamidopyridin-4-yl)-2-(methylsulfanyl)-1H-imidazol-5-yl]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-9-carboxamide, ... | 著者 | Ogboo, B.C, Beyett, T.S, Eck, M.J, Heppner, D.E. | 登録日 | 2023-01-18 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem, 7, 2024
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8GC7
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8GC8
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8GB4
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8GVJ
| Crystal structure of cMET kinase domain bound by D6808 | 分子名称: | (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor | 著者 | Chen, Y.H, Qu, L.Z. | 登録日 | 2022-09-15 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
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8H7F
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8H7H
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8GW3
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8H75
| FGFR2 in complex with YJ001 | 分子名称: | CHLORIDE ION, Fibroblast growth factor receptor 2, Tinengotinib | 著者 | Yan, X.E, Yun, C.H. | 登録日 | 2022-10-19 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | 主引用文献 | FGFR2 in complex with YJ001 To Be Published
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8H7X
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8HY7
| EGFR kinase domain mutant "TMLR" with compound 28f | 分子名称: | Epidermal growth factor receptor, ~{N}-[3-[[6-fluoranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide | 著者 | Wang, Y.X, Wu, C.Y. | 登録日 | 2023-01-06 | 公開日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | The crystal structure of EGFR kinase domain(T790M/L858R) in complex with compound 28f To Be Published
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8HOA
| ScRIPK mutant K124R | 分子名称: | (2R,5R)-hexane-2,5-diol, ADENOSINE-5'-TRIPHOSPHATE, FORMIC ACID, ... | 著者 | Fang, J.L, Zhang, M.Q, Ming, Z.H. | 登録日 | 2022-12-09 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.676 Å) | 主引用文献 | Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance in Arabidopsis. Front Plant Sci, 14, 2023
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8HOD
| ScRIPK MUTANT-S253A, T254A | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Hypothetical protein | 著者 | Fang, J.L, Zhang, M.Q. | 登録日 | 2022-12-09 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Receptor-like cytoplasmic kinase ScRIPK in sugarcane regulates disease resistance and drought tolerance in Arabidopsis. Front Plant Sci, 14, 2023
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8HAQ
| The complex of Src with GW8510 | 分子名称: | 4-[(~{E})-(7-oxidanyl-6~{H}-pyrrolo[2,3-g][1,3]benzothiazol-8-yl)methylideneamino]-~{N}-pyridin-2-yl-benzenesulfonamide, Isoform 2 of Proto-oncogene tyrosine-protein kinase Src | 著者 | Zhu, S.J, Bi, S.Z. | 登録日 | 2022-10-26 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | The complex of Src with GW8510 To Be Published
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8HMT
| The complex of ACK1 with the inhibitor 2-142 | 分子名称: | 6-(2-bromophenyl)-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[[(2S)-oxolan-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one, Activated CDC42 kinase 1 | 著者 | Zhu, S, Xiaoyun, X.Y. | 登録日 | 2022-12-05 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | The complex of ACK1 with the inhibitor 2-142 To Be Published
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8HVA
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8HV1
| Crystal structure of EGFR_DMX in complex with covalently bound fragment 1 | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 3-(3-bromophenyl)-1,4-dihydro-1,2,4-triazole-5-thione, Epidermal growth factor receptor, ... | 著者 | Dokurno, P. | 登録日 | 2022-12-26 | 公開日 | 2023-12-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase. Rsc Med Chem, 14, 2023
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8HV4
| Crystal structure of EGFR_TMX in complex with covalently bound fragment 4 | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Dokurno, P. | 登録日 | 2022-12-26 | 公開日 | 2023-12-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase. Rsc Med Chem, 14, 2023
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8HV5
| Crystal structure of EGFR_DMX in complex with compound 7 | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Epidermal growth factor receptor, ~{N}-(1-methylbenzimidazol-4-yl)prop-2-enamide | 著者 | Dokurno, P. | 登録日 | 2022-12-26 | 公開日 | 2023-12-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase. Rsc Med Chem, 14, 2023
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8HV3
| Crystal structure of EGFR_DMX in complex with covalently bound fragment 4 | 分子名称: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DIMETHYL SULFOXIDE, Epidermal growth factor receptor, ... | 著者 | Dokurno, P. | 登録日 | 2022-12-26 | 公開日 | 2023-12-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase. Rsc Med Chem, 14, 2023
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