8H7X
Crystal structure of EGFR T790M/C797S mutant in complex with brigatinib
Summary for 8H7X
Entry DOI | 10.2210/pdb8h7x/pdb |
Descriptor | Epidermal growth factor receptor, 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine (2 entities in total) |
Functional Keywords | inhibitor, complex, protein kinase, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 75739.05 |
Authors | Kukimoto-Niino, M.,Shirouzu, M. (deposition date: 2022-10-21, release date: 2023-10-25, Last modification date: 2024-03-06) |
Primary citation | Suzuki, M.,Uchibori, K.,Oh-Hara, T.,Nomura, Y.,Suzuki, R.,Takemoto, A.,Araki, M.,Matsumoto, S.,Sagae, Y.,Kukimoto-Niino, M.,Kawase, Y.,Shirouzu, M.,Okuno, Y.,Nishio, M.,Fujita, N.,Katayama, R. A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer. NPJ Precis Oncol, 8:46-46, 2024 Cited by PubMed: 38396251DOI: 10.1038/s41698-024-00542-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.404 Å) |
Structure validation
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