8H7X

Crystal structure of EGFR T790M/C797S mutant in complex with brigatinib

Summary for 8H7X

Entry DOI	10.2210/pdb8h7x/pdb
Descriptor	Epidermal growth factor receptor, 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine (2 entities in total)
Functional Keywords	inhibitor, complex, protein kinase, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	75739.05
Authors	Kukimoto-Niino, M.,Shirouzu, M. (deposition date: 2022-10-21, release date: 2023-10-25, Last modification date: 2024-03-06)
Primary citation	Suzuki, M.,Uchibori, K.,Oh-Hara, T.,Nomura, Y.,Suzuki, R.,Takemoto, A.,Araki, M.,Matsumoto, S.,Sagae, Y.,Kukimoto-Niino, M.,Kawase, Y.,Shirouzu, M.,Okuno, Y.,Nishio, M.,Fujita, N.,Katayama, R. A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer. NPJ Precis Oncol, 8:46-46, 2024 Cited by PubMed: 38396251 DOI: 10.1038/s41698-024-00542-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.404 Å)

Structure validation