8H7X
Crystal structure of EGFR T790M/C797S mutant in complex with brigatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 330 | 37577.5 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | C (A) | 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | non-polymer | 584.1 | 1 | Chemie (6GY) |
Sequence modifications
A, B: 696 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 693 | - | expression tag |
| Ala 694 | - | expression tag |
| Met 695 | - | expression tag |
| Met 790 | Thr 790 | engineered mutation |
| Ser 797 | Cys 797 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75155.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 584.1 | |
| All* | Total formula weight | 75739.1 |
