8H7F

The crystal structure of human abl1 kinase domain in complex with abl1-B-EBA

Summary for 8H7F

Entry DOI	10.2210/pdb8h7f/pdb
Descriptor	Tyrosine-protein kinase ABL1, 1-[6-(6-methoxyisoquinolin-7-yl)-1,3-benzothiazol-2-yl]-3-(2-oxidanylideneethyl)urea (3 entities in total)
Functional Keywords	complex, inhibitor, lysine, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	64910.04
Authors	Zhu, C.J.,Zhang, Z.M. (deposition date: 2022-10-20, release date: 2023-03-01, Last modification date: 2024-02-07)
Primary citation	Chen, P.,Tang, G.,Zhu, C.,Sun, J.,Wang, X.,Xiang, M.,Huang, H.,Wang, W.,Li, L.,Zhang, Z.M.,Gao, L.,Yao, S.Q. 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J.Am.Chem.Soc., 2023 Cited by PubMed: 36774655 DOI: 10.1021/jacs.2c11595 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4501342407 Å)

Structure validation