8FV4

EGFR(T790M/V948R) in complex with compound 2 (LN5993)

Summary for 8FV4

• Entry DOI: 10.2210/pdb8fv4/pdb
• Descriptor: Epidermal growth factor receptor, N-{(3P)-3-[(4P)-4-(2-acetamidopyridin-4-yl)-2-(methylsulfanyl)-1H-imidazol-5-yl]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-9-carboxamide, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 151554.11

Authors

Ogboo, B.C.,Beyett, T.S.,Eck, M.J.,Heppner, D.E. (deposition date: 2023-01-18, release date: 2024-01-17, Last modification date: 2024-03-20)

• Primary citation: Wittlinger, F.,Ogboo, B.C.,Shevchenko, E.,Damghani, T.,Pham, C.D.,Schaeffner, I.K.,Oligny, B.T.,Chitnis, S.P.,Beyett, T.S.,Rasch, A.,Buckley, B.,Urul, D.A.,Shaurova, T.,May, E.W.,Schaefer, E.M.,Eck, M.J.,Hershberger, P.A.,Poso, A.,Laufer, S.A.,Heppner, D.E.; Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.; Commun Chem, 7:38-38, 2024; PubMed: 38378740; DOI: 10.1038/s42004-024-01108-3

Experimental method

X-RAY DIFFRACTION (2.2 Å)