5QIN
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN IN COMPLEX WITH N- {4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2- YL]PYRIDIN-2-YL}ACETAMIDE
Summary for 5QIN
Entry DOI | 10.2210/pdb5qin/pdb |
Group deposition | TGFBR (G_1002052) |
Descriptor | TGF-beta receptor type-2, N-{4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kinase domain, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36316.46 |
Authors | Sheriff, S. (deposition date: 2018-08-05, release date: 2018-10-31, Last modification date: 2024-03-06) |
Primary citation | Zhang, Y.,Zhao, Y.,Tebben, A.J.,Sheriff, S.,Ruzanov, M.,Fereshteh, M.P.,Fan, Y.,Lippy, J.,Swanson, J.,Ho, C.P.,Wautlet, B.S.,Rose, A.,Parrish, K.,Yang, Z.,Donnell, A.F.,Zhang, L.,Fink, B.E.,Vite, G.D.,Augustine-Rauch, K.,Fargnoli, J.,Borzilleri, R.M. Discovery of 4-Azaindole Inhibitors of TGF beta RI as Immuno-oncology Agents. ACS Med Chem Lett, 9:1117-1122, 2018 Cited by PubMed: 30429955DOI: 10.1021/acsmedchemlett.8b00357 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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