7ZA2
| GPC3-Unc5D octamer structure and role in cell migration | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glypican-3, ... | Authors: | Akkermans, O, Delloye-Bourgeois, C, Peregrina, C, Carrasquero, M, Kokolaki, M, Berbeira-Santana, M, Chavent, M, Reynaud, F, Ritu, R, Agirre, J, Aksu, M, White, E, Lowe, E, Ben Amar, D, Zaballa, S, Huo, J, Pakos, I, McCubbin, P, Comoletti, D, Owens, R, Robinson, C, Castellani, V, del Toro, D, Seiradake, E. | Deposit date: | 2022-03-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.6 Å) | Cite: | GPC3-Unc5 receptor complex structure and role in cell migration. Cell, 185, 2022
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7ZA1
| GPC3-Unc5D octamer structure and role in cell migration | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glypican-3, ... | Authors: | Akkermans, O, Delloye-Bourgeois, C, Peregrina, C, Carrasquero, M, Kokolaki, M, Berbeira-Santana, M, Chavent, M, Reynaud, F, Ritu, R, Agirre, J, Aksu, M, White, E, Lowe, E, Ben Amar, D, Zaballa, S, Huo, J, Pakos, I, McCubbin, P, Comoletti, D, Owens, R, Robinson, C, Castellani, V, del Toro, D, Seiradake, E. | Deposit date: | 2022-03-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | GPC3-Unc5 receptor complex structure and role in cell migration. Cell, 185, 2022
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7ZA3
| GPC3-Unc5D octamer structure and role in cell migration | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glypican-3, ... | Authors: | Akkermans, O, Delloye-Bourgeois, C, Peregrina, C, Carrasquero, M, Kokolaki, M, Berbeira-Santana, M, Chavent, M, Reynaud, F, Ritu, R, Agirre, J, Aksu, M, White, E, Lowe, E, Ben Amar, D, Zaballa, S, Huo, J, Pakos, I, McCubbin, P, Comoletti, D, Owens, R, Robinson, C, Castellani, V, del Toro, D, Seiradake, E. | Deposit date: | 2022-03-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | GPC3-Unc5 receptor complex structure and role in cell migration. Cell, 185, 2022
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8A1F
| Human PTPRK N-terminal domains MAM-Ig-FN1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Hay, I.M, Graham, S.C, Sharpe, H.J, Deane, J.E. | Deposit date: | 2022-06-01 | Release date: | 2023-03-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains. J.Biol.Chem., 299, 2023
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1CVS
| CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX | Descriptor: | FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION | Authors: | Plotnikov, A.N, Schlessinger, J, Hubbard, S.R, Mohammadi, M. | Deposit date: | 1999-08-24 | Release date: | 2000-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for FGF receptor dimerization and activation. Cell(Cambridge,Mass.), 98, 1999
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1DJS
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1E0O
| CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, ... | Authors: | Pellegrini, L, Burke, D.F, von Delft, F, Mulloy, B, Blundell, T.L. | Deposit date: | 2000-04-03 | Release date: | 2000-10-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin Nature, 407, 2000
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2NZI
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1EV2
| CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2) | Descriptor: | PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION | Authors: | Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M. | Deposit date: | 2000-04-19 | Release date: | 2000-05-31 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell(Cambridge,Mass.), 101, 2000
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1EVT
| CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1) | Descriptor: | PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION | Authors: | Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M. | Deposit date: | 2000-04-20 | Release date: | 2000-05-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell(Cambridge,Mass.), 101, 2000
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1FQ9
| CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX | Descriptor: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 2, ... | Authors: | Schlessinger, J, Plotnikov, A.N, Ibrahimi, O.A, Eliseenkova, A.V, Yeh, B.K, Yayon, A, Linhardt, R.J, Mohammadi, M. | Deposit date: | 2000-09-04 | Release date: | 2000-09-27 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol.Cell, 6, 2000
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4OQT
| LINGO-1/Li81 Fab complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Li81 Fab, ... | Authors: | Pepinsky, R.B, Arndt, J.W, Quan, C, Gao, Y, Quintero-Monzon, O, Lee, X, Mi, S. | Deposit date: | 2014-02-10 | Release date: | 2014-05-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | Structure of the LINGO-1-Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy. J.Pharmacol.Exp.Ther., 350, 2014
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4PBV
| Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NT-3 growth factor receptor, Protein-tyrosine phosphatase CRYPalpha1 isoform, ... | Authors: | Coles, C.H, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, A.W, Nakagawa, T, Craig, A.M, Jones, E.Y, Aricescu, A.R. | Deposit date: | 2014-04-14 | Release date: | 2014-11-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis. Nat Commun, 5, 2014
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4PBX
| Crystal structure of the six N-terminal domains of human receptor protein tyrosine phosphatase sigma | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase S | Authors: | Coles, C.H, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, A.W, Nakagawa, T, Craig, A.M, Jones, E.Y, Aricescu, A.R. | Deposit date: | 2014-04-14 | Release date: | 2014-11-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis. Nat Commun, 5, 2014
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4PBW
| Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NT-3 growth factor receptor, Protein-tyrosine phosphatase CRYPalpha1 isoform | Authors: | Coles, C.H, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, A.W, Nakagawa, T, Craig, A.M, Jones, E.Y, Aricescu, A.R. | Deposit date: | 2014-04-14 | Release date: | 2014-11-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis. Nat Commun, 5, 2014
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6CXI
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6CXJ
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2FDB
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6DLF
| Crystal structure of NTRI homodimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neurotrimin | Authors: | Ranaivoson, F.M, Turk, L.S, Ozkan, E, Montelione, G.T, Comoletti, D. | Deposit date: | 2018-06-01 | Release date: | 2019-04-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.446 Å) | Cite: | Structure of a heterodimer of neuronal cell surface proteins Structure, 2019
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6EFY
| Crystal Structure of DIP-Alpha Ig1-3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Dpr-interacting protein alpha, isoform A, ... | Authors: | Cosmanescu, F, Shapiro, L. | Deposit date: | 2018-08-17 | Release date: | 2018-11-28 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins. Neuron, 100, 2018
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6FF3
| Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I | Descriptor: | Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2 | Authors: | Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M. | Deposit date: | 2018-01-03 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
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6FEY
| Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin | Descriptor: | Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5 | Authors: | Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D. | Deposit date: | 2018-01-03 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
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3OJM
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3OJV
| Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop | Descriptor: | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Basic fibroblast growth factor receptor 1, Heparin-binding growth factor 1 | Authors: | Beenken, A, Mohammadi, M. | Deposit date: | 2010-08-23 | Release date: | 2011-12-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287, 2012
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6G2T
| human cardiac myosin binding protein C C1 Ig-domain bound to native cardiac thin filament | Descriptor: | Actin, cytoplasmic 2, Myosin-binding protein C, ... | Authors: | Risi, C, Belknap, B, Forgacs, E, Harris, S.P, Schroder, G.F, White, H.D, Galkin, V.E. | Deposit date: | 2018-03-23 | Release date: | 2018-10-17 | Last modified: | 2018-12-19 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament. Structure, 26, 2018
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