3OJV

Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop

Summary for 3OJV

• Entry DOI: 10.2210/pdb3ojv/pdb
• Related: 1DJS 1EVT 1RY7 3OJ2 3OJM
• Descriptor: Heparin-binding growth factor 1, Basic fibroblast growth factor receptor 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: beta trefoil motif, immunoglobulin-like domain, growth factor, growth factor receptor, extracellular, cytokine-signaling protein complex, cytokine/signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 83325.15

Authors

Beenken, A.,Mohammadi, M. (deposition date: 2010-08-23, release date: 2011-12-28, Last modification date: 2023-09-06)

• Primary citation: Beenken, A.,Eliseenkova, A.V.,Ibrahimi, O.A.,Olsen, S.K.,Mohammadi, M.; Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1.; J.Biol.Chem., 287:3067-3078, 2012; PubMed: 22057274; DOI: 10.1074/jbc.M111.275891

Experimental method

X-RAY DIFFRACTION (2.6 Å)