3OJV
Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heparin-binding growth factor 1 | polymer | 136 | 15420.4 | 2 | UniProt (P05230) Pfam (PF00167) | Homo sapiens (human) | HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta |
| 2 | C, D (C, D) | Basic fibroblast growth factor receptor 1 | polymer | 226 | 25376.0 | 2 | UniProt (P11362) Pfam (PF07679) | Homo sapiens (human) | bFGF-R-1, FGFR-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, FLT-2 |
| 3 | E (E) | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 1732.4 | 1 | In PDB GlyTouCan (G26920WX) | |||
| 4 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 155 (UniProt: P05230)
C, D: 142 - 365 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Met 20 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 140 | - | initiating methionine |
| Ala 141 | - | expression tag |
| Gln 185 | Asn 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 81592.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1732.4 | |
| All* | Total formula weight | 83325.2 |
