3OJV

Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008083	molecular_function	growth factor activity
B	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00247
Number of Residues	24
Details	HBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY

Chain	Residue	Details
A	GLY86-TYR109

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	66
Details	Region: {"description":"Heparin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"Nuclear localization signal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11069186","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9655399","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	176
Details	Domain: {"description":"Ig-like C2-type 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	204
Details	Domain: {"description":"Ig-like C2-type 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---