PDB: 83 件ウェブページステータス検索Chemie searchBIRD

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8U89	The structure of the PP2A-B56Delta holoenzyme mutant - E197K 分子名称: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Wu, C.G, Xing, Y. 登録日 2023-09-16 公開日 2024-01-10 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121, 2024
8U1X	The structure of the PP2A-B56Delta holoenzyme mutant - E197K 分子名称: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Wu, C.G, Xing, Y. 登録日 2023-09-04 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 B56 delta long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations. Proc.Natl.Acad.Sci.USA, 121, 2024
8TWI	Cryo-EM structure of the PP2A:B55-FAM122A complex, PP2Ac body 分子名称: FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. 登録日 2023-08-21 公開日 2023-11-01 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.69 Å) 主引用文献 Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
8TWE	Cryo-EM structure of the PP2A:B55-FAM122A complex, B55 body 分子名称: PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. 登録日 2023-08-21 公開日 2023-11-01 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.55 Å) 主引用文献 Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
8TTB	Cryo-EM structure of the PP2A:B55-ARPP19 complex 分子名称: FE (III) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. 登録日 2023-08-13 公開日 2023-10-25 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.77 Å) 主引用文献 Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
8SO0	Cryo-EM structure of the PP2A:B55-FAM122A complex 分子名称: FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ... 著者 Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. 登録日 2023-04-28 公開日 2023-10-25 最終更新日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.79961 Å) 主引用文献 Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
8SGH	Cryo-EM structure of Karyopherin-beta2 bound to HNRNPH2 PY-NLS 分子名称: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed, Transportin-1 著者 Gonzalez, A, Fung, H.Y.J, Chook, Y.M. 登録日 2023-04-12 公開日 2023-06-14 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 A new Karyopherin-beta 2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders. Structure, 31, 2023
8RC4	Structure of Integrator-PP2A complex 分子名称: DSS1, Integrator complex subunit 1, Integrator complex subunit 10, ... 著者 Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. 登録日 2023-12-06 公開日 2024-02-07 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 2024
8RBZ	Structure of Integrator-PP2A-SOSS-CTD post-termination complex 分子名称: DNA-directed RNA polymerase subunit, DSS1, Integrator complex subunit 1, ... 著者 Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. 登録日 2023-12-05 公開日 2024-02-07 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 2024
8RBX	Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. 登録日 2023-12-05 公開日 2024-02-07 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 2024
8ERA	RMC-5552 in complex with mTORC1 and FKBP12 分子名称: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... 著者 Tomlinson, A.C.A, Yano, J.K. 登録日 2022-10-11 公開日 2022-12-28 最終更新日 2023-01-25 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023
7YCX	The structure of INTAC-PEC complex 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... 著者 Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. 登録日 2022-07-02 公開日 2023-03-15 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (4.18 Å) 主引用文献 Structural basis of INTAC-regulated transcription. Protein Cell, 14, 2023
7XVK	Modularity of Phytophthora effectors enables host mimicry of a principal phosphatase 分子名称: 1,2-ETHANEDIOL, RxLR effector protein PSR2, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 著者 Wang, J, Wang, Y. 登録日 2022-05-24 公開日 2023-07-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Pathogen protein modularity enables elaborate mimicry of a host phosphatase. Cell, 186, 2023
7VPW	Crystal structure of Transportin-1 in complex with BAP1 PY-NLS (residues 706-724) 分子名称: BRCA1-associated protein 1 (BAP1), Transportin-1 著者 Yang, T.J, Hsu, S.T.D. 登録日 2021-10-18 公開日 2022-04-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.76 Å) 主引用文献 Tumor suppressor BAP1 nuclear import is governed by transportin-1. J.Cell Biol., 221, 2022
7UXH	cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Cui, Z, Hurley, J. 登録日 2022-05-05 公開日 2022-11-30 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
7UXC	cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Cui, Z, Hurley, J. 登録日 2022-05-05 公開日 2022-11-30 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
7UX2	cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Cui, Z, Hurley, J. 登録日 2022-05-04 公開日 2022-11-30 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
7SOY	The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex 分子名称: Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y. 登録日 2021-11-01 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition. Elife, 11, 2022
7PQH	Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains). 分子名称: Serine/threonine-protein kinase TOR2, Target of rapamycin complex 1 subunit KOG1,Target of rapamycin complex 1 subunit Kog1, Target of rapamycin complex subunit LST8 著者 Felix, J, Prouteau, M, Bourgoint, C, Bonadei, L, Desfosses, A, Gabus, C, Sadian, Y, Savvides, S.N, Gutsche, I, Loewith, R. 登録日 2021-09-17 公開日 2023-01-18 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3.87 Å) 主引用文献 EGOC inhibits TOROID polymerization by structurally activating TORC1. Nat.Struct.Mol.Biol., 30, 2023
7PKS	Structural basis of Integrator-mediated transcription regulation 分子名称: DNA Template, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... 著者 Fianu, I, Chen, Y, Dienemann, C, Cramer, P. 登録日 2021-08-26 公開日 2021-12-08 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of Integrator-mediated transcription regulation. Science, 374, 2021
7PEC	cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (4.24 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEB	cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEA	cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement 分子名称: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... 著者 Waelchli, M, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (4.07 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7OWG	human DEPTOR in a complex with mutant human mTORC1 A1459P 分子名称: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... 著者 Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2022-02-23 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
7K36	Cryo-EM structure of STRIPAK complex 分子名称: INOSITOL HEXAKISPHOSPHATE, MANGANESE (II) ION, MOB-like protein phocein, ... 著者 Jeong, B.-C, Bai, X.C. 登録日 2020-09-10 公開日 2021-03-10 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of the Hippo signaling integrator human STRIPAK. Nat.Struct.Mol.Biol., 28, 2021

 

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