PDB: 156 件ウェブページステータス検索Chemie searchBIRD

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1RV1	CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR 分子名称: CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE, Ubiquitin-protein ligase E3 Mdm2 著者 Lukacs, C, Kammlott, U, Graves, B. 登録日 2003-12-12 公開日 2004-01-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science, 303, 2004
6V4G	Crystal Structure Analysis of Zebra fish MDMX 分子名称: Protein Mdm4, SULFATE ION, Stapled peptide QSQQTF(0EH)NLWRLE(MK8)QN(NH2) 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2019-11-27 公開日 2020-04-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
5C5A	Crystal Structure of HDM2 in complex with Nutlin-3a 分子名称: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Orts, J, Waelti, M.A, Marsh, M, Vera, L, Gossert, A.D, Guentert, P, Riek, R. 登録日 2015-06-19 公開日 2016-06-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.146 Å) 主引用文献 NMR Molecular Replacement, NMR2 To Be Published
1T4F	Structure of human MDM2 in complex with an optimized p53 peptide 分子名称: SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, optimized p53 peptide 著者 Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J. 登録日 2004-04-29 公開日 2005-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J.Med.Chem., 48, 2005
1T4E	Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor 分子名称: (4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID, Ubiquitin-protein ligase E3 Mdm2 著者 Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J. 登録日 2004-04-29 公開日 2005-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J.Med.Chem., 48, 2005
1TTV	NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor 分子名称: 1-{[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]CARBONYL}PIPERAZINE, Ubiquitin-protein ligase E3 Mdm2 著者 Fry, D.C, Emerson, S.D, Palme, S, Vu, B.T, Liu, C.M, Podlaski, F. 登録日 2004-06-23 公開日 2005-01-04 最終更新日 2021-10-27 実験手法 SOLUTION NMR 主引用文献 NMR structure of a complex between MDM2 and a small molecule inhibitor. J.Biomol.Nmr, 30, 2004
1UHR	Solution structure of the SWIB domain of mouse BRG1-associated factor 60a 分子名称: SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily D member 1 著者 Yamada, K, Saito, K, Nameki, N, Inoue, M, Koshiba, S, Shirouzu, M, Terada, T, Yabuki, T, Aoki, M, Matsuda, T, Seki, E, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-07-09 公開日 2004-08-24 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SWIB domain of mouse BRG1-associated factor 60a To be Published
1V31	Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana 分子名称: hypothetical protein RAFL11-05-P19 著者 Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-10-21 公開日 2004-04-21 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana To be Published
1V32	Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana 分子名称: hypothetical protein RAFL09-47-K03 著者 Yoneyama, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-10-24 公開日 2004-04-24 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana To be Published
7AD0	X-ray structure of Mdm2 with modified p53 peptide 分子名称: E3 ubiquitin-protein ligase Mdm2, Modified p53 peptide 著者 Twarda-Clapa, A, Fortuna, P, Grudnik, P, Dubin, G, Berlicki, L, Holak, T.A. 登録日 2020-09-13 公開日 2020-10-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Systematic ""foldamerization"" of peptide inhibiting p53-MDM2/X interactions by the incorporation of trans- or cis-2-aminocyclopentanecarboxylic acid residues Eur.J.Med.Chem., 208, 2020
7BJ6	Inhibitor of MDM2-p53 Interaction 分子名称: (3~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-3-(4-chlorophenyl)-4-fluoranyl-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-6-(2-oxidanylpropan-2-yl)isoindol-1-one, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... 著者 Williams, P.A. 登録日 2021-01-14 公開日 2021-04-07 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
7BJ0	Inhibitor of MDM2-p53 Interaction 分子名称: (3~{R})-4-chloranyl-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-2-[(4-nitrophenyl)methyl]isoindol-1-one, E3 ubiquitin-protein ligase Mdm2 著者 Williams, P.A. 登録日 2021-01-13 公開日 2021-04-07 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
7BMG	Inhibitor of MDM2-p53 Interaction 分子名称: (3~{R})-3-(4-chlorophenyl)-2-[(4-ethynylphenyl)methyl]-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-6-(2-oxidanylpropan-2-yl)isoindol-1-one, 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2 著者 Williams, P.A. 登録日 2021-01-20 公開日 2021-04-07 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
7BIT	Inhibitor of MDM2-p53 Interaction 分子名称: (3~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-3-(4-chlorophenyl)-4-fluoranyl-3-[(1-oxidanylcyclopropyl)methoxy]-6-(2-oxidanylpropan-2-yl)isoindol-1-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Williams, P.A. 登録日 2021-01-13 公開日 2021-04-07 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
7BIV	Inhibitor of MDM2-p53 Interaction 分子名称: 1,2-ETHANEDIOL, 6-[[(1~{R})-1-(4-chlorophenyl)-7-fluoranyl-1-[[1-(hydroxymethyl)cyclopropyl]methoxy]-3-oxidanylidene-5-(2-oxidanylpropan-2-yl)isoindol-2-yl]methyl]pyridine-3-carbonitrile, DIMETHYL SULFOXIDE, ... 著者 Williams, P.A. 登録日 2021-01-13 公開日 2021-04-07 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
7BIR	Inhibitor of MDM2-p53 Interaction 分子名称: 1-[[(1~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-1-(4-chlorophenyl)-7-fluoranyl-3-oxidanylidene-5-(2-oxidanylpropan-2-yl)isoindol-1-yl]oxymethyl]cyclopropane-1-carboxamide, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Williams, P.A. 登録日 2021-01-13 公開日 2021-04-07 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
3IWY	Crystal structure of human MDM2 complexed with D-peptide (12 residues) 分子名称: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 著者 Pazgier, M, Lu, W. 登録日 2009-09-03 公開日 2010-04-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398, 2010
3IUX	Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues) 分子名称: ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Pazgier, M, Lu, W. 登録日 2009-08-31 公開日 2009-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Apamin as a template for structure-based rational design of potent peptide activators of p53. Angew.Chem.Int.Ed.Engl., 48, 2009
3JZS	Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ) 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2, pDIQ peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-24 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
3JZK	crystal structure of MDM2 with chromenotriazolopyrimidine 1 分子名称: (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine, E3 ubiquitin-protein ligase Mdm2 著者 Huang, X. 登録日 2009-09-23 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J.Med.Chem., 52, 2009
3JZR	Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W) 分子名称: E3 ubiquitin-protein ligase Mdm2, pDI6W peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-24 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
8EBK	Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog 分子名称: ACE-LEU-THR-PHE-0EH-GLU-TYR-TRP-ALA-GLN-LEU-MK8-SER-ALA-ALA, HDMX 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2022-08-31 公開日 2023-10-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog To Be Published
8F10	Structure of the MDM2 P53 binding domain in complex with H102, an all-D Helicon Polypeptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. 登録日 2022-11-04 公開日 2023-02-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
8F0Z	Structure of the MDM2 P53 binding domain in complex with H101, an all-D Helicon Polypeptide 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, H101, ... 著者 Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. 登録日 2022-11-04 公開日 2023-02-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023
8F13	Structure of the MDM2 P53 binding domain in complex with H103, an all-D Helicon Polypeptide, alternative C-terminus 分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, E3 ubiquitin-protein ligase Mdm2, ... 著者 Li, K, Callahan, A.J, Travaline, T.L, Tokareva, O.S, Swiecicki, J.-M, Verdine, G.L, Pentelute, B.L, McGee, J.H. 登録日 2022-11-04 公開日 2023-02-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display Chemrxiv, 2023

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