7BIR

Inhibitor of MDM2-p53 Interaction

Summary for 7BIR

• Entry DOI: 10.2210/pdb7bir/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, 1-[[(1~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-1-(4-chlorophenyl)-7-fluoranyl-3-oxidanylidene-5-(2-oxidanylpropan-2-yl)isoindol-1-yl]oxymethyl]cyclopropane-1-carboxamide, ... (4 entities in total)
• Functional Keywords: ligase, cell cycle, apoptosis, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 11931.64

Authors

Williams, P.A. (deposition date: 2021-01-13, release date: 2021-04-07, Last modification date: 2021-04-21)

• Primary citation: Chessari, G.,Hardcastle, I.R.,Ahn, J.S.,Anil, B.,Anscombe, E.,Bawn, R.H.,Bevan, L.D.,Blackburn, T.J.,Buck, I.,Cano, C.,Carbain, B.,Castro, J.,Cons, B.,Cully, S.J.,Endicott, J.A.,Fazal, L.,Golding, B.T.,Griffin, R.J.,Haggerty, K.,Harnor, S.J.,Hearn, K.,Hobson, S.,Holvey, R.S.,Howard, S.,Jennings, C.E.,Johnson, C.N.,Lunec, J.,Miller, D.C.,Newell, D.R.,Noble, M.E.M.,Reeks, J.,Revill, C.H.,Riedinger, C.,St Denis, J.D.,Tamanini, E.,Thomas, H.,Thompson, N.T.,Vinkovic, M.,Wedge, S.R.,Williams, P.A.,Wilsher, N.E.,Zhang, B.,Zhao, Y.; Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.; J.Med.Chem., 64:4071-4088, 2021; PubMed: 33761253; DOI: 10.1021/acs.jmedchem.0c02188

Experimental method

X-RAY DIFFRACTION (2.02 Å)