7BJ0
Inhibitor of MDM2-p53 Interaction
Summary for 7BJ0
Entry DOI | 10.2210/pdb7bj0/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, (3~{R})-4-chloranyl-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-2-[(4-nitrophenyl)methyl]isoindol-1-one (3 entities in total) |
Functional Keywords | ligase, cell cycle, apoptosis, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 26804.14 |
Authors | Williams, P.A. (deposition date: 2021-01-13, release date: 2021-04-07, Last modification date: 2024-05-15) |
Primary citation | Chessari, G.,Hardcastle, I.R.,Ahn, J.S.,Anil, B.,Anscombe, E.,Bawn, R.H.,Bevan, L.D.,Blackburn, T.J.,Buck, I.,Cano, C.,Carbain, B.,Castro, J.,Cons, B.,Cully, S.J.,Endicott, J.A.,Fazal, L.,Golding, B.T.,Griffin, R.J.,Haggerty, K.,Harnor, S.J.,Hearn, K.,Hobson, S.,Holvey, R.S.,Howard, S.,Jennings, C.E.,Johnson, C.N.,Lunec, J.,Miller, D.C.,Newell, D.R.,Noble, M.E.M.,Reeks, J.,Revill, C.H.,Riedinger, C.,St Denis, J.D.,Tamanini, E.,Thomas, H.,Thompson, N.T.,Vinkovic, M.,Wedge, S.R.,Williams, P.A.,Wilsher, N.E.,Zhang, B.,Zhao, Y. Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64:4071-4088, 2021 Cited by PubMed: 33761253DOI: 10.1021/acs.jmedchem.0c02188 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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