7BJ0
Inhibitor of MDM2-p53 Interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | E3 ubiquitin-protein ligase Mdm2 | polymer | 114 | 12888.7 | 2 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | A, B | (3~{R})-4-chloranyl-3-(4-chlorophenyl)-3-[[1-(hydroxymethyl)cyclopropyl]methoxy]-2-[(4-nitrophenyl)methyl]isoindol-1-one | non-polymer | 513.4 | 2 | Chemie (TVH) | |||
| 3 | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ala 51 | Lys 51 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25777.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1026.7 | |
| All* | Total formula weight | 26804.1 |
