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4XN1	Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Glutamate Descriptor: Aminopeptidase N, GLUTAMIC ACID, MALONATE ION, ... Authors: Addlagatta, A, Gumpena, R. Deposit date: 2015-01-15 Release date: 2016-03-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Glutamate To Be Published
4XNB	Crystal Structure of E. coli Aminopeptidase N in complex with L-Beta Homophenylalanine Descriptor: (3S)-3-AMINO-4-PHENYLBUTANOIC ACID, Aminopeptidase N, GLYCEROL, ... Authors: Addlagatta, A, Gumpena, R. Deposit date: 2015-01-15 Release date: 2016-03-02 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of E. coli Aminopeptidase N in complex with L-Beta Homophenylalanine To Be Published
4ZW5	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9f Descriptor: M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX5	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZW6	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX6	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZW8	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9r Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZW7	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9m Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX3	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10b Descriptor: DIMETHYL SULFOXIDE, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZW3	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b Descriptor: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-19 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
4ZX4	X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... Authors: Drinkwater, N, McGowan, S. Deposit date: 2015-05-20 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016
5BPP	Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ Descriptor: 2-(4-butoxyphenyl)-N-hydroxyacetamide, ACETATE ION, Leukotriene A-4 hydrolase, ... Authors: Huang, J, Dong, N.N, Xiao, Q, Ou, P.Y, Wu, D, Lu, W.Q. Deposit date: 2015-05-28 Release date: 2016-08-10 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H Sci Rep, 6, 2016
5FWQ	Apo structure of human Leukotriene A4 hydrolase Descriptor: ACETATE ION, HUMAN LEUKOTRIENE A4 HYDROLASE, IMIDAZOLE, ... Authors: Wittmann, S.K, Kalinowsky, L, Kramer, J, Bloecher, R, Steinhilber, D, Pogoryelov, D, Proschak, E, Heering, J. Deposit date: 2016-02-19 Release date: 2016-10-05 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.047 Å) Cite: Thermodynamic properties of leukotriene A4hydrolase inhibitors. Bioorg.Med.Chem., 24, 2016
5J6S	Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand Descriptor: (2S)-N~1~-benzyl-2-[(4-fluorophenyl)methyl]-N~3~-hydroxypropanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Saridakis, E, Giastas, P, Mpakali, A, Deprez-Poulain, R, Stratikos, E. Deposit date: 2016-04-05 Release date: 2017-03-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett, 8, 2017
5N3W	Crystal structure of LTA4H bound to a selective inhibitor against LTB4 generation Descriptor: 3-[2-(2-hydroxyphenyl)ethyl]-5-methoxy-phenol, ACETATE ION, IMIDAZOLE, ... Authors: Wong, C.T, Low, C.M, Snelgrove, R.J, Hare, S.A. Deposit date: 2017-02-09 Release date: 2017-03-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The development of novel LTA4H modulators to selectively target LTB4 generation. Sci Rep, 7, 2017
5K1V	Crystal structure of Endoplasmic Reticulum aminopeptidase 2 (ERAP2) in complex with a diaminobenzoic acid derivative ligand. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 2, ... Authors: Saridakis, E, Papakyriakou, A, Giastas, P, Mpakali, A, Mavridis, I.M, Stratikos, E. Deposit date: 2016-05-18 Release date: 2017-03-29 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.897 Å) Cite: Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett, 8, 2017
5LDS	Structure of the porcine aminopeptidase N ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... Authors: Santiago, C, Reguera, J, Mudgal, G, Casasnovas, J.M. Deposit date: 2016-06-27 Release date: 2017-04-05 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection. Sci Rep, 7, 2017
5LHD	Structure of glycosylated human aminopeptidase N Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Recacha, R, Mudgal, G, Santiago, C, Casasnovas, J.M. Deposit date: 2016-07-11 Release date: 2017-04-05 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection. Sci Rep, 7, 2017
5MJ6	Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... Authors: Mpakali, A, Stratikos, E, Saridakis, E, Giastas, P. Deposit date: 2016-11-30 Release date: 2017-04-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity. J. Med. Chem., 60, 2017
5LG6	Structure of the deglycosylated porcine aminopeptidase N ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ZINC ION Authors: Santiago, C, Reguera, J, Mudgal, G, Casasnovas, J.M. Deposit date: 2016-07-06 Release date: 2017-04-12 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection. Sci Rep, 7, 2017
5MFT	The crystal structure of E. coli Aminopeptidase N in complex with 7-amino-1-bromo-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one Descriptor: Aminopeptidase N, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Peng, G, Olieric, V, McEwen, A.G, Schmitt, C, Albrecht, S, Cavarelli, J, Tarnus, C. Deposit date: 2016-11-18 Release date: 2017-04-19 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis. Proteins, 85, 2017
5MFR	The crystal structure of E. coli Aminopeptidase N in complex with 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one Descriptor: Aminopeptidase N, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Peng, G, Olieric, V, McEwen, A.G, Schmitt, C, Albrecht, S, Cavarelli, J, Tarnus, C. Deposit date: 2016-11-18 Release date: 2017-04-19 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis. Proteins, 85, 2017
5MFS	The crystal structure of E. coli Aminopeptidase N in complex with 7-amino-4-phenyl-5,7,8,9-tetrahydrobenzocyclohepten-6-one Descriptor: Aminopeptidase N, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Peng, G, Olieric, V, McEwen, A.G, Schmitt, C, Albrecht, S, Cavarelli, J, Tarnus, C. Deposit date: 2016-11-18 Release date: 2017-04-19 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis. Proteins, 85, 2017
5NI2	Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form I) Descriptor: 5S-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid, Leukotriene A-4 hydrolase, YTTERBIUM (III) ION, ... Authors: Stsiapanava, A. Deposit date: 2017-03-23 Release date: 2017-08-23 Last modified: 2017-09-13 Method: X-RAY DIFFRACTION (1.501 Å) Cite: Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NIE	Crystal structure of human LTA4H mutant R563A in open conformation Descriptor: Leukotriene A-4 hydrolase, ZINC ION Authors: Stsiapanava, A. Deposit date: 2017-03-23 Release date: 2017-08-23 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.603 Å) Cite: Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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