5N3W
Crystal structure of LTA4H bound to a selective inhibitor against LTB4 generation
Summary for 5N3W
Entry DOI | 10.2210/pdb5n3w/pdb |
Descriptor | Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (7 entities in total) |
Functional Keywords | hydrolase, inflammation |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P09960 |
Total number of polymer chains | 1 |
Total formula weight | 71017.95 |
Authors | Wong, C.T.,Low, C.M.,Snelgrove, R.J.,Hare, S.A. (deposition date: 2017-02-09, release date: 2017-03-29, Last modification date: 2024-01-17) |
Primary citation | Low, C.M.,Akthar, S.,Patel, D.F.,Loser, S.,Wong, C.T.,Jackson, P.L.,Blalock, J.E.,Hare, S.A.,Lloyd, C.M.,Snelgrove, R.J. The development of novel LTA4H modulators to selectively target LTB4 generation. Sci Rep, 7:44449-44449, 2017 Cited by PubMed: 28303931DOI: 10.1038/srep44449 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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