5BPP

Structure of human Leukotriene A4 hydrolase in complex with inhibitor 4AZ

Summary for 5BPP

• Entry DOI: 10.2210/pdb5bpp/pdb
• Related: 5AEN
• Descriptor: Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, inflammation, enzyme, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P09960
• Total number of polymer chains: 1
• Total formula weight: 72402.17

Authors

Huang, J.,Dong, N.N.,Xiao, Q.,Ou, P.Y.,Wu, D.,Lu, W.Q. (deposition date: 2015-05-28, release date: 2016-08-10, Last modification date: 2024-03-20)

• Primary citation: Xiao, Q.,Dong, N.N.,Yao, X.,Wu, D.,Lu, Y.,Mao, F.,Zhu, J.,Li, J.,Huang, J.,Chen, A.,Huang, L.,Wang, X.,Yang, G.,He, G.,Xu, Y.,Lu, W.Q.; Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H; Sci Rep, 6:25298-25298, 2016; PubMed: 27126280; DOI: 10.1038/srep25298

Experimental method

X-RAY DIFFRACTION (2.03 Å)