5AEN

Structure of human Leukotriene A4 hydrolase in complex with inhibitor dimethyl(2- (4-phenoxyphenoxy)ethyl)amine

Summary for 5AEN

Entry DOI	10.2210/pdb5aen/pdb
Descriptor	LEUKOTRIENE A-4 HYDROLASE, N,N-dimethyl-2-(4-phenoxyphenoxy)ethanamine, ZINC ION, ... (6 entities in total)
Functional Keywords	hydrolase, leukotriene (lt) a4 hydrolase/aminopeptidase, lta4h
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	70159.61
Authors	Moser, D.,Wittmann, S.K.,Kramer, J.,Blocher, R.,Achenbach, J.,Pogoryelov, D.,Proschak, E. (deposition date: 2015-01-06, release date: 2015-02-11, Last modification date: 2024-01-10)
Primary citation	Moser, D.,Wittmann, S.K.,Kramer, J.,Blocher, R.,Achenbach, J.,Pogoryelov, D.,Proschak, E. Peng: A Neural Gas-Based Approach for Pharmacophore Elucidation. Method Design, Validation and Virtual Screening for Novel Ligands of Lta4H. J.Chem.Inf.Model., 55:284-, 2015 Cited by PubMed: 25625859 DOI: 10.1021/CI500618U PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.864 Å)

Structure validation